Research output per year
Research output per year
Personal profile
Personal profile
Emmanuelle is mainly interested in ribosomal complexes of translation initiation. She studies archaeal organisms and is also interested in bacteria and eukaryotes to better understand how the translation initiation mechanisms have evolved. She uses X-ray crystallography, SAXS and cryo-EM to perform structural studies and she also developed biochemical strategies for functional studies.
Research interests
Biochemistry, Genetics and Molecular Biology, Chemestry
Education/Academic qualification
HDR (PhD Supervision Credentials)
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Collaborations and top research areas from the last five years
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A family of ribosome hibernation factors widespread in Archaea
Madru, C., Bourgeois, G., Dulermo, R., Capeyrou, R., Joncour, G., Figuigui, K., Duchateau, M., Chamot-Rooke, J., Duboc, C., l’Haridon, S., Mc Teer, L., Kwapisz, M., Clouet-d’Orval, B., Bouvier, M., Mechulam, Y., Borrel, G., Schmitt, E. & Flament, D., 1 Dec 2026, In: Nature Communications . 17, 1, 5751.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Evolutionary Convergence on a Dihydrofolate Reductase Mutation Drives Trimethoprim–Sulfamethoxazole Resistance in Burkholderia thailandensis
Guillier, S., Lazennec-Schurdevin, C., Mondange, L., Sarilar, V., Marchandeau, M., Lemoigne, C., Lamer, O., Lescat, M., Schmitt, E., Mechulam, Y., Garrec, J. & Biot, F., 14 Aug 2026, In: ACS Infectious Diseases. 12, 8, p. 2627-2641 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cys-tRNAj as a Second Translation Initiator for Priming Proteins with Cysteine in Bacteria
Paupelin-Vaucelle, H., Boschiero, C., Lazennec-Schurdevin, C., Schmitt, E., Mechulam, Y., Marlière, P. & Pezo, V., 11 Feb 2025, In: ACS Omega. 10, 5, p. 4548-4560 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Structures of Saccharolobus solfataricus initiation complexes with leaderless mRNAs highlight archaeal features and eukaryotic proximity
Bourgeois, G., Coureux, P. D., Lazennec-Schurdevin, C., Madru, C., Gaillard, T., Duchateau, M., Chamot-Rooke, J., Bourcier, S., Mechulam, Y. & Schmitt, E., 1 Dec 2025, In: Nature Communications . 16, 1, 348.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Translation in Archaea
Schmitt, E. & Mechulam, Y., 1 Jan 2025, Biology of Archaea 2: Molecular Biology of Archaea, From Genome Maintenance to the Regulation of Gene Expression. wiley, p. 193-232 40 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Structural insights into the evolution of late steps of translation initiation in the three domains of life
Kazan, R., Bourgeois, G., Lazennec-Schurdevin, C., Coureux, P. D., Mechulam, Y. & Schmitt, E., 1 Feb 2024, In: Biochimie. 217, p. 31-41 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access5 Citations (Scopus) -
Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells
Fedry, J., Silva, J., Vanevic, M., Fronik, S., Mechulam, Y., Schmitt, E., des Georges, A., Faller, W. J. & Förster, F., 21 Mar 2024, In: Molecular Cell. 84, 6, p. 1078-1089.e4Research output: Contribution to journal › Article › peer-review
Open Access28 Citations (Scopus) -
Binding of human Cdc123 to eIF2γ
Cardenal Peralta, C., Vandroux, P., Neumann-Arnold, L., Panvert, M., Fagart, J., Seufert, W., Mechulam, Y. & Schmitt, E., 1 Sept 2023, In: Journal of Structural Biology. 215, 3, 108006.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Grid batch-dependent tuning of glow discharge parameters
Kazan, R., Bourgeois, G., Carisetti, D., Florea, I., Larquet, E., Maurice, J. L., Mechulam, Y., Ozanam, F., Schmitt, E. & Coureux, P. D., 18 Aug 2022, In: Frontiers in Molecular Biosciences. 9, 910218.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Medical contrast agents as promising tools for biomacromolecular SAXS experiments
Gabel, F., Engilberge, S., Schmitt, E., Thureau, A., Mechulam, Y., Pérez, J., Girard, E. & Czjzek, M., 1 Sept 2022, In: Acta Crystallographica Section D: Structural Biology. 78, Pt 9, p. 1120-1130 11 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus)