Personal profile
Research Interests
Marc Graille's research is focusing on translation termination and its coupling to degradation of normal or aberrant mRNAs in eukaryotes, using structural and biochemical methods to unravel the mechanisms of these processes at the molecular level.
Research interests
Education/Academic qualification
HDR (PhD Supervision Credentials)
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Collaborations and top research areas from the last five years
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RNA anchoring of Upf1 facilitates recruitment of Dcp2 in the NMD decapping complex
Ruiz-Gutierrez, N., Dupas, J., Auquier, E., Barbarin-Bocahu, I., Gaudon-Plesse, C., Saveanu, C., Graille, M. & Le Hir, H., 24 Mar 2025, In: Nucleic Acids Research. 53, 5, gkaf160.Research output: Contribution to journal › Article › peer-review
Open Access -
InsPection of electron density maps supports wrongly modeled hexakisphosphate (InsP6) bound to African swine fever mRNA-decapping enzyme g5Rp
Graille, M., 1 May 2024, In: Journal of virology. 98, 5Research output: Contribution to journal › Comment/debate
Open Access -
Structure of the Nmd4-Upf1 complex supports conservation of the nonsense-mediated mRNA decay pathway between yeast and humans
Barbarin-Bocahu, I., Ulryck, N., Rigobert, A., Gutierrez, N. R., Decourty, L., Raji, M., Garkhal, B., Le Hir, H., Saveanu, C. & Graille, M., 1 Sept 2024, In: PLoS Biology. 22, 9, e3002821.Research output: Contribution to journal › Article › peer-review
Open Access -
Best Practices of Using AI-Based Models in Crystallography and Their Impact in Structural Biology
Graille, M., Sacquin-Mora, S. & Taly, A., 26 Jun 2023, In: Journal of Chemical Information and Modeling. 63, 12, p. 3637-3646 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
ERH: a plug-and-play protein important for gene silencing and cell cycle progression
Graille, M., 1 Feb 2023, In: FEBS Journal. 290, 3, p. 688-691 4 p.Research output: Contribution to journal › Comment/debate
Open Access -
Erratum: The X-ray crystallography phase problem solved thanks to AlphaFold and RoseTTAFold models: a case-study report. Corrigendum (Acta crystallographica. Section D, Structural biology (2022) 78 Pt 4 (517-531))
Barbarin-Bocahu, I. & Graille, M., 1 Apr 2023, In: Acta Crystallographica Section D: Structural Biology. 79, p. 353 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
N2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing
Wang, C., Ulryck, N., Herzel, L., Pythoud, N., Kleiber, N., Guérineau, V., Jactel, V., Moritz, C., Bohnsack, M. T., Carapito, C., Touboul, D., Bohnsack, K. E. & Graille, M., 11 Aug 2023, In: Nucleic Acids Research. 51, 14, p. 7496-7519 24 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cg1246, a new player in mycolic acid biosynthesis in Corynebacterium glutamicum
de Sousa-D'Auria, C., Constantinesco, F., Bayan, N., Constant, P., Tropis, M., Daffé, M., Graille, M. & Houssin, C., 1 Jan 2022, In: Microbiology (United Kingdom). 168, 4, 001171.Research output: Contribution to journal › Article › peer-review
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Division of labor in epitranscriptomics: What have we learnt from the structures of eukaryotic and viral multimeric RNA methyltransferases?
Graille, M., 1 Jan 2022, In: Wiley Interdisciplinary Reviews: RNA. 13, 1, e1673.Research output: Contribution to journal › Review article › peer-review
Open Access -
The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex
Zou, L., Moch, C., Graille, M. & Chapat, C., 15 Jul 2022, In: iScience. 25, 7, 104646.Research output: Contribution to journal › Article › peer-review
Open Access