Personal profile
Personal profile
Yves Mechulam undertakes interdisciplinary study in the fields of Gene and Molecular biology through his works. Borrowing concepts from Gene, Yves Mechulam weaves in ideas under Molecular biology. He combines Biochemistry and DNA in his research. RNA and Aminoacyl tRNA synthetase are two areas of study in which Yves Mechulam engages in interdisciplinary research. He connects Aminoacyl tRNA synthetase with Transfer RNA in his study. In his papers, Yves Mechulam integrates diverse fields, such as Transfer RNA and Aminoacylation. Yves Mechulam performs multidisciplinary study in Aminoacylation and RNA in his work. In his works, he conducts interdisciplinary research on Enzyme and Stereochemistry. By researching both Stereochemistry and Enzyme, he produces research that crosses academic boundaries.
Research interests
Education/Academic qualification
HDR (PhD Supervision Credentials)
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Collaborations and top research areas from the last five years
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Cys-tRNAj as a Second Translation Initiator for Priming Proteins with Cysteine in Bacteria
Paupelin-Vaucelle, H., Boschiero, C., Lazennec-Schurdevin, C., Schmitt, E., Mechulam, Y., Marlière, P. & Pezo, V., 11 Feb 2025, In: ACS Omega. 10, 5, p. 4548-4560 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Structures of Saccharolobus solfataricus initiation complexes with leaderless mRNAs highlight archaeal features and eukaryotic proximity
Bourgeois, G., Coureux, P. D., Lazennec-Schurdevin, C., Madru, C., Gaillard, T., Duchateau, M., Chamot-Rooke, J., Bourcier, S., Mechulam, Y. & Schmitt, E., 1 Dec 2025, In: Nature Communications. 16, 1, 348.Research output: Contribution to journal › Article › peer-review
Open Access -
Translation in Archaea
Schmitt, E. & Mechulam, Y., 1 Jan 2025, Biology of Archaea 2: Molecular Biology of Archaea, From Genome Maintenance to the Regulation of Gene Expression. wiley, p. 193-232 40 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Structural insights into the evolution of late steps of translation initiation in the three domains of life
Kazan, R., Bourgeois, G., Lazennec-Schurdevin, C., Coureux, P. D., Mechulam, Y. & Schmitt, E., 1 Feb 2024, In: Biochimie. 217, p. 31-41 11 p.Research output: Contribution to journal › Review article › peer-review
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Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells
Fedry, J., Silva, J., Vanevic, M., Fronik, S., Mechulam, Y., Schmitt, E., des Georges, A., Faller, W. J. & Förster, F., 21 Mar 2024, In: Molecular Cell. 84, 6, p. 1078-1089.e4Research output: Contribution to journal › Article › peer-review
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Binding of human Cdc123 to eIF2γ
Cardenal Peralta, C., Vandroux, P., Neumann-Arnold, L., Panvert, M., Fagart, J., Seufert, W., Mechulam, Y. & Schmitt, E., 1 Sept 2023, In: Journal of Structural Biology. 215, 3, 108006.Research output: Contribution to journal › Article › peer-review
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Redesigning methionyl-tRNA synthetase for β-methionine activity with adaptive landscape flattening and experiments
Opuu, V., Nigro, G., Lazennec-Schurdevin, C., Mechulam, Y., Schmitt, E. & Simonson, T., 1 Sept 2023, In: Protein Science. 32, 9, e4738.Research output: Contribution to journal › Article › peer-review
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Grid batch-dependent tuning of glow discharge parameters
Kazan, R., Bourgeois, G., Carisetti, D., Florea, I., Larquet, E., Maurice, J. L., Mechulam, Y., Ozanam, F., Schmitt, E. & Coureux, P. D., 18 Aug 2022, In: Frontiers in Molecular Biosciences. 9, 910218.Research output: Contribution to journal › Article › peer-review
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Medical contrast agents as promising tools for biomacromolecular SAXS experiments
Gabel, F., Engilberge, S., Schmitt, E., Thureau, A., Mechulam, Y., Pérez, J., Girard, E. & Czjzek, M., 1 Sept 2022, In: Acta Crystallographica Section D: Structural Biology. 78, Pt 9, p. 1120-1130 11 p.Research output: Contribution to journal › Article › peer-review
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Role of aIF5B in archaeal translation initiation
Kazan, R., Bourgeois, G., Lazennec-Schurdevin, C., Larquet, E., Mechulam, Y., Coureux, P. D. & Schmitt, E., 24 Jun 2022, In: Nucleic Acids Research. 50, 11, p. 6532-6548 17 p.Research output: Contribution to journal › Article › peer-review
Open Access