3-Acylated tetramic and tetronic acids as natural metal binders: Myth or reality?

Mehdi Zaghouani; Bastien Nay

doi:10.1039/c5np00144g

3-Acylated tetramic and tetronic acids as natural metal binders: Myth or reality?

Mehdi Zaghouani
, Bastien Nay

CNRS/Museum National d'Histoire Naturelle/IRD/UPMC

Research output: Contribution to journal › Review article › peer-review

Abstract

Covering: up to 2015 3-Acylated tetramic and tetronic acids are characterized by a low pK_a and are likely to be deprotonated under physiological conditions. In addition, their structure makes them excellent chelators of metallic cations. We will discuss the significance of these chemical properties with regard to the biological properties and mechanisms of action of these compounds, highlighting the importance of considering them as salts or chelates for biological purposes, rather than acids.

Original language	English
Pages (from-to)	540-548
Number of pages	9
Journal	Natural Product Reports
Volume	33
Issue number	4
DOIs	https://doi.org/10.1039/c5np00144g
Publication status	Published - 1 Apr 2016
Externally published	Yes

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10.1039/c5np00144g

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title = "3-Acylated tetramic and tetronic acids as natural metal binders: Myth or reality?",

abstract = "Covering: up to 2015 3-Acylated tetramic and tetronic acids are characterized by a low pKa and are likely to be deprotonated under physiological conditions. In addition, their structure makes them excellent chelators of metallic cations. We will discuss the significance of these chemical properties with regard to the biological properties and mechanisms of action of these compounds, highlighting the importance of considering them as salts or chelates for biological purposes, rather than acids.",

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AU - Nay, Bastien

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N2 - Covering: up to 2015 3-Acylated tetramic and tetronic acids are characterized by a low pKa and are likely to be deprotonated under physiological conditions. In addition, their structure makes them excellent chelators of metallic cations. We will discuss the significance of these chemical properties with regard to the biological properties and mechanisms of action of these compounds, highlighting the importance of considering them as salts or chelates for biological purposes, rather than acids.

AB - Covering: up to 2015 3-Acylated tetramic and tetronic acids are characterized by a low pKa and are likely to be deprotonated under physiological conditions. In addition, their structure makes them excellent chelators of metallic cations. We will discuss the significance of these chemical properties with regard to the biological properties and mechanisms of action of these compounds, highlighting the importance of considering them as salts or chelates for biological purposes, rather than acids.

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3-Acylated tetramic and tetronic acids as natural metal binders: Myth or reality?

Abstract

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