A common framework for linear and cyclic multiple sequence alignment problems

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Abstract

Circularized RNAs have received considerable attention is the last few years following the discovery that they are not only a rather common phenomenon in the transcriptomes of Eukarya and Archaea but also may have key regulatory functions. This calls for the adaptation of basic tools of sequence analysis to accommodate cyclic sequences. Here we discuss a common formal framework for linear and circular alignments as partitions that preserve (cyclic) order. We focus on the similarities and differences and describe a prototypical ILP formulation.

Original languageEnglish
Title of host publicationAlgorithms in Bioinformatics - 14th International Workshop, WABI 2014, Proceedings
PublisherSpringer Verlag
Pages135-147
Number of pages13
ISBN (Print)9783662447529
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes
Event14th International Workshop on Algorithms in Bioinformatics, WABI 2014 - Wroclaw, Poland
Duration: 8 Sept 201410 Sept 2014

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8701 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference14th International Workshop on Algorithms in Bioinformatics, WABI 2014
Country/TerritoryPoland
CityWroclaw
Period8/09/1410/09/14

Keywords

  • circular RNAs
  • cyclic orders
  • cyclic sequence alignment
  • integer linear programming
  • multiple sequence alignment

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