A convergent approach to functionalised alkynes

Jean Boivin; Sylvain Huppé; Samir Z. Zard

doi:10.1016/S0040-4039(96)02015-1

A convergent approach to functionalised alkynes

Jean Boivin
, Sylvain Huppé
, Samir Z. Zard

Laboratoire de Synthèse Organique

Research output: Contribution to journal › Article › peer-review

Abstract

Knoevenagel type condensation of 4-unsubstituted isoxazolinones with ketones or aldehydes followed by Michael addition of a nucleophile - hydride, cyanide, or phosphite - and exposure of the adduct to sodium nitrite/aqueous acetic acid and ferrous sulfate gives variously functionalised alkynes.

Original language	English
Pages (from-to)	8735-8738
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	48
DOIs	https://doi.org/10.1016/S0040-4039(96)02015-1
Publication status	Published - 25 Nov 1996

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@article{384c05b4210d410587efecf81924b7eb,

title = "A convergent approach to functionalised alkynes",

abstract = "Knoevenagel type condensation of 4-unsubstituted isoxazolinones with ketones or aldehydes followed by Michael addition of a nucleophile - hydride, cyanide, or phosphite - and exposure of the adduct to sodium nitrite/aqueous acetic acid and ferrous sulfate gives variously functionalised alkynes.",

author = "Jean Boivin and Sylvain Hupp{\'e} and Zard, \{Samir Z.\}",

year = "1996",

month = nov,

day = "25",

doi = "10.1016/S0040-4039(96)02015-1",

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T1 - A convergent approach to functionalised alkynes

AU - Boivin, Jean

AU - Huppé, Sylvain

AU - Zard, Samir Z.

PY - 1996/11/25

Y1 - 1996/11/25

N2 - Knoevenagel type condensation of 4-unsubstituted isoxazolinones with ketones or aldehydes followed by Michael addition of a nucleophile - hydride, cyanide, or phosphite - and exposure of the adduct to sodium nitrite/aqueous acetic acid and ferrous sulfate gives variously functionalised alkynes.

AB - Knoevenagel type condensation of 4-unsubstituted isoxazolinones with ketones or aldehydes followed by Michael addition of a nucleophile - hydride, cyanide, or phosphite - and exposure of the adduct to sodium nitrite/aqueous acetic acid and ferrous sulfate gives variously functionalised alkynes.

UR - https://www.scopus.com/pages/publications/0030602161

U2 - 10.1016/S0040-4039(96)02015-1

DO - 10.1016/S0040-4039(96)02015-1

M3 - Article

AN - SCOPUS:0030602161

SN - 0040-4039

VL - 37

SP - 8735

EP - 8738

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 48

ER -

A convergent approach to functionalised alkynes

Abstract

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