A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes

Pierre Salomon; Wioletta Kosnik; Samir Z. Zard

doi:10.1016/j.tet.2014.11.021

A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes

Pierre Salomon
, Wioletta Kosnik
, Samir Z. Zard

Laboratoire de Synthèse Organique

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated magnesium metal.

Original language	English
Article number	26170
Pages (from-to)	7144-7153
Number of pages	10
Journal	Tetrahedron
Volume	71
Issue number	39
DOIs	https://doi.org/10.1016/j.tet.2014.11.021
Publication status	Published - 17 Aug 2015
Externally published	Yes

Keywords

Fluorine
Radical addition
Xanthates

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10.1016/j.tet.2014.11.021

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title = "A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes",

abstract = "Abstract An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated magnesium metal.",

keywords = "Fluorine, Radical addition, Xanthates",

author = "Pierre Salomon and Wioletta Kosnik and Zard, \{Samir Z.\}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd.",

year = "2015",

month = aug,

day = "17",

doi = "10.1016/j.tet.2014.11.021",

language = "English",

volume = "71",

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journal = "Tetrahedron",

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TY - JOUR

T1 - A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes

AU - Salomon, Pierre

AU - Kosnik, Wioletta

AU - Zard, Samir Z.

PY - 2015/8/17

Y1 - 2015/8/17

N2 - Abstract An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated magnesium metal.

AB - Abstract An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated magnesium metal.

KW - Fluorine

KW - Radical addition

KW - Xanthates

U2 - 10.1016/j.tet.2014.11.021

DO - 10.1016/j.tet.2014.11.021

M3 - Article

AN - SCOPUS:84939255091

SN - 0040-4020

VL - 71

SP - 7144

EP - 7153

JO - Tetrahedron

JF - Tetrahedron

IS - 39

M1 - 26170

ER -

A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes

Abstract

Keywords

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