A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

Shi Guang Li; Fernando Portela-Cubillo; Samir Z. Zard

doi:10.1021/acs.orglett.6b00656

A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

Shi Guang Li
, Fernando Portela-Cubillo
, Samir Z. Zard

Laboratoire de Synthèse Organique

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino acids ideally equipped for native chemical ligation.

Original language	English
Pages (from-to)	1888-1891
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	8
DOIs	https://doi.org/10.1021/acs.orglett.6b00656
Publication status	Published - 15 Apr 2016
Externally published	Yes

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title = "A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids",

abstract = "A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino acids ideally equipped for native chemical ligation.",

author = "Li, \{Shi Guang\} and Fernando Portela-Cubillo and Zard, \{Samir Z.\}",

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AU - Li, Shi Guang

AU - Portela-Cubillo, Fernando

AU - Zard, Samir Z.

PY - 2016/4/15

Y1 - 2016/4/15

N2 - A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino acids ideally equipped for native chemical ligation.

AB - A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino acids ideally equipped for native chemical ligation.

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DO - 10.1021/acs.orglett.6b00656

M3 - Article

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AN - SCOPUS:84966393386

SN - 1523-7060

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EP - 1891

JO - Organic Letters

JF - Organic Letters

IS - 8

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A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

Abstract

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