A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

Aurore De Rache; Nassima Meriem Gueddouda; Anne Bourdoncle; Paul Hommes; Hans Ulrich Reissig; Jean Louis Mergny

doi:10.1002/chem.201603021

A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

Aurore De Rache
, Nassima Meriem Gueddouda
, Anne Bourdoncle
, Paul Hommes
, Hans Ulrich Reissig
, Jean Louis Mergny

Research output: Contribution to journal › Article › peer-review

Abstract

G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and¹H NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.

Original language	English
Pages (from-to)	12651-12654
Number of pages	4
Journal	Chemistry - A European Journal
Volume	22
Issue number	36
DOIs	https://doi.org/10.1002/chem.201603021
Publication status	Published - 26 Aug 2016
Externally published	Yes

Keywords

G-quadruplex
G4 ligand
bipyridine
helicase
terpyridine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/chem.201603021

Cite this

@article{54f76d4a73af4049b2301463bc47f866,

title = "A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes",

abstract = "G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and1H NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.",

keywords = "G-quadruplex, G4 ligand, bipyridine, helicase, terpyridine",

author = "\{De Rache\}, Aurore and Gueddouda, \{Nassima Meriem\} and Anne Bourdoncle and Paul Hommes and Reissig, \{Hans Ulrich\} and Mergny, \{Jean Louis\}",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2016",

month = aug,

day = "26",

doi = "10.1002/chem.201603021",

language = "English",

volume = "22",

pages = "12651--12654",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

number = "36",

}

TY - JOUR

T1 - A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

AU - De Rache, Aurore

AU - Gueddouda, Nassima Meriem

AU - Bourdoncle, Anne

AU - Hommes, Paul

AU - Reissig, Hans Ulrich

AU - Mergny, Jean Louis

PY - 2016/8/26

Y1 - 2016/8/26

N2 - G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and1H NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.

AB - G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and1H NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.

KW - G-quadruplex

KW - G4 ligand

KW - bipyridine

KW - helicase

KW - terpyridine

U2 - 10.1002/chem.201603021

DO - 10.1002/chem.201603021

M3 - Article

C2 - 27410717

AN - SCOPUS:84983247102

SN - 0947-6539

VL - 22

SP - 12651

EP - 12654

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 36

ER -

A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this