A new convergent approach to α-branched alkynes

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Abstract

A variety of α-branched alkynes can be easily assembled by a Knoevenagel type condensation of 4-unsubstituted isoxazolin-5-ones with aldehydes or ketones, followed by conjugate addition of an organometallic reagent and nitrosative cleavage of the heterocyclic ring.

Original languageEnglish
Pages (from-to)1257-1260
Number of pages4
JournalSynlett
Issue number8
DOIs
Publication statusPublished - 1 Jan 2002
Externally publishedYes

Keywords

  • Alkynes
  • Conjugate addition
  • Isoxazolin-5-ones
  • Knoevenagel condensation

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