A new MAFia in cancer

Alain Eychène; Nathalie Rocques; Celio Pouponnot

doi:10.1038/nrc2460

A new MAFia in cancer

Alain Eychène
, Nathalie Rocques
, Celio Pouponnot

Research output: Contribution to journal › Review article › peer-review

Abstract

Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer - overexpression of the large Maf genes promotes the development of multiple myeloma - they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.

Original language	English
Pages (from-to)	683-693
Number of pages	11
Journal	Nature Reviews Cancer
Volume	8
Issue number	9
DOIs	https://doi.org/10.1038/nrc2460
Publication status	Published - 1 Sept 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/nrc2460

Cite this

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title = "A new MAFia in cancer",

abstract = "Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer - overexpression of the large Maf genes promotes the development of multiple myeloma - they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.",

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year = "2008",

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AU - Eychène, Alain

AU - Rocques, Nathalie

AU - Pouponnot, Celio

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N2 - Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer - overexpression of the large Maf genes promotes the development of multiple myeloma - they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.

AB - Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer - overexpression of the large Maf genes promotes the development of multiple myeloma - they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma.

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DO - 10.1038/nrc2460

M3 - Review article

C2 - 19143053

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EP - 693

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 9

ER -

A new MAFia in cancer

Abstract

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