A novel minimal motif for left-handed G-quadruplex formation

Poulomi Das; Fernaldo Richtia Winnerdy; Arijit Maity; Yves Mechulam; Anh Tuân Phan

doi:10.1039/d0cc08146a

A novel minimal motif for left-handed G-quadruplex formation

Poulomi Das
, Fernaldo Richtia Winnerdy
, Arijit Maity
, Yves Mechulam
, Anh Tuân Phan

Research output: Contribution to journal › Article › peer-review

Abstract

A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.

Original language	English
Pages (from-to)	2527-2530
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	20
DOIs	https://doi.org/10.1039/d0cc08146a
Publication status	Published - 11 Mar 2021

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title = "A novel minimal motif for left-handed G-quadruplex formation",

abstract = "A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.",

author = "Poulomi Das and Winnerdy, \{Fernaldo Richtia\} and Arijit Maity and Yves Mechulam and Phan, \{Anh Tu{\^a}n\}",

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doi = "10.1039/d0cc08146a",

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AU - Das, Poulomi

AU - Winnerdy, Fernaldo Richtia

AU - Maity, Arijit

AU - Mechulam, Yves

AU - Phan, Anh Tuân

N1 - Publisher Copyright: © The Royal Society of Chemistry 2021.

PY - 2021/3/11

Y1 - 2021/3/11

N2 - A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.

AB - A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.

U2 - 10.1039/d0cc08146a

DO - 10.1039/d0cc08146a

M3 - Article

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VL - 57

SP - 2527

EP - 2530

JO - Chemical Communications

JF - Chemical Communications

IS - 20

ER -

A novel minimal motif for left-handed G-quadruplex formation

Abstract

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