A practical source of chlorodifluoromethyl radicals. Convergent routes to gem -difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols

Pierre Salomon; Samir Z. Zard

doi:10.1021/ol501063a

A practical source of chlorodifluoromethyl radicals. Convergent routes to gem -difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols

Pierre Salomon
, Samir Z. Zard

Laboratoire de Synthèse Organique

Research output: Contribution to journal › Article › peer-review

Abstract

The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols.

Original language	English
Pages (from-to)	2926-2929
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	11
DOIs	https://doi.org/10.1021/ol501063a
Publication status	Published - 6 Jun 2014
Externally published	Yes

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10.1021/ol501063a

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title = "A practical source of chlorodifluoromethyl radicals. Convergent routes to gem -difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols",

abstract = "The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols.",

author = "Pierre Salomon and Zard, \{Samir Z.\}",

year = "2014",

month = jun,

day = "6",

doi = "10.1021/ol501063a",

language = "English",

volume = "16",

pages = "2926--2929",

journal = "Organic Letters",

issn = "1523-7060",

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T1 - A practical source of chlorodifluoromethyl radicals. Convergent routes to gem -difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols

AU - Salomon, Pierre

AU - Zard, Samir Z.

PY - 2014/6/6

Y1 - 2014/6/6

N2 - The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols.

AB - The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols.

U2 - 10.1021/ol501063a

DO - 10.1021/ol501063a

M3 - Article

AN - SCOPUS:84902096263

SN - 1523-7060

VL - 16

SP - 2926

EP - 2929

JO - Organic Letters

JF - Organic Letters

IS - 11

ER -

A practical source of chlorodifluoromethyl radicals. Convergent routes to gem -difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols

Abstract

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