A simple synthesis of functionalized 3-bromocoumarins by a one-pot three-component reaction

Davide Audisio; Samir Messaoudi; Jean Daniel Brion; Mouâd Alami

doi:10.1002/ejoc.200901107

A simple synthesis of functionalized 3-bromocoumarins by a one-pot three-component reaction

Davide Audisio
, Samir Messaoudi
, Jean Daniel Brion
, Mouâd Alami

Université Paris-Saclay

Research output: Contribution to journal › Article › peer-review

Abstract

Functionalized 3-bromocoumarins 2 have been, prepared, by a simple one-pot bromination/Wittig/cyclization tandem process from methyl (triphenylphosphoranylidene)acetate, Nbromosuccinimide and a series of 2-hydroxybenzaldehydes. Owing to the commercial availability of salicylaldehyde derivatives, this approach offers such a diverse range of compounds that it fulfills the recent demand for the generation of large combinatorial chemical libraries based on the coumarin scaffold

Original language	English
Pages (from-to)	1046-1051
Number of pages	6
Journal	European Journal of Organic Chemistry
Issue number	6
DOIs	https://doi.org/10.1002/ejoc.200901107
Publication status	Published - 1 Feb 2010
Externally published	Yes

Keywords

Bromine
Multicomponent reactions
Natural products
Oxygen heterocycles
Wittig reactions

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10.1002/ejoc.200901107

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abstract = "Functionalized 3-bromocoumarins 2 have been, prepared, by a simple one-pot bromination/Wittig/cyclization tandem process from methyl (triphenylphosphoranylidene)acetate, Nbromosuccinimide and a series of 2-hydroxybenzaldehydes. Owing to the commercial availability of salicylaldehyde derivatives, this approach offers such a diverse range of compounds that it fulfills the recent demand for the generation of large combinatorial chemical libraries based on the coumarin scaffold",

keywords = "Bromine, Multicomponent reactions, Natural products, Oxygen heterocycles, Wittig reactions",

author = "Davide Audisio and Samir Messaoudi and Brion, \{Jean Daniel\} and Mou{\^a}d Alami",

year = "2010",

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doi = "10.1002/ejoc.200901107",

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AU - Audisio, Davide

AU - Messaoudi, Samir

AU - Brion, Jean Daniel

AU - Alami, Mouâd

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Functionalized 3-bromocoumarins 2 have been, prepared, by a simple one-pot bromination/Wittig/cyclization tandem process from methyl (triphenylphosphoranylidene)acetate, Nbromosuccinimide and a series of 2-hydroxybenzaldehydes. Owing to the commercial availability of salicylaldehyde derivatives, this approach offers such a diverse range of compounds that it fulfills the recent demand for the generation of large combinatorial chemical libraries based on the coumarin scaffold

AB - Functionalized 3-bromocoumarins 2 have been, prepared, by a simple one-pot bromination/Wittig/cyclization tandem process from methyl (triphenylphosphoranylidene)acetate, Nbromosuccinimide and a series of 2-hydroxybenzaldehydes. Owing to the commercial availability of salicylaldehyde derivatives, this approach offers such a diverse range of compounds that it fulfills the recent demand for the generation of large combinatorial chemical libraries based on the coumarin scaffold

KW - Bromine

KW - Multicomponent reactions

KW - Natural products

KW - Oxygen heterocycles

KW - Wittig reactions

UR - https://www.scopus.com/pages/publications/76449107018

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JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 6

ER -

A simple synthesis of functionalized 3-bromocoumarins by a one-pot three-component reaction

Abstract

Keywords

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