Actin flows mediate a universal coupling between cell speed and cell persistence

Paolo Maiuri; Jean François Rupprecht; Stefan Wieser; Verena Ruprecht; Olivier Bénichou; Nicolas Carpi; Mathieu Coppey; Simon De Beco; Nir Gov; Carl Philipp Heisenberg; Carolina Lage Crespo; Franziska Lautenschlaeger; Maël Le Berre; Ana Maria Lennon-Dumenil; Matthew Raab; Hawa Racine Thiam; Matthieu Piel; Michael Sixt; Raphaël Voituriez

doi:10.1016/j.cell.2015.01.056

Actin flows mediate a universal coupling between cell speed and cell persistence

Paolo Maiuri, Jean François Rupprecht, Stefan Wieser, Verena Ruprecht, Olivier Bénichou, Nicolas Carpi, Mathieu Coppey, Simon De Beco, Nir Gov, Carl Philipp Heisenberg, Carolina Lage Crespo, Franziska Lautenschlaeger, Maël Le Berre, Ana Maria Lennon-Dumenil, Matthew Raab, Hawa Racine Thiam, Matthieu Piel, Michael Sixt, Raphaël Voituriez

Research output: Contribution to journal › Article › peer-review

Abstract

Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns.

Original language	English
Pages (from-to)	374-386
Number of pages	13
Journal	Cell
Volume	161
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2015.01.056
Publication status	Published - 9 Apr 2015
Externally published	Yes

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Maiuri, P., Rupprecht, J. F., Wieser, S., Ruprecht, V., Bénichou, O., Carpi, N., Coppey, M., De Beco, S., Gov, N., Heisenberg, C. P., Lage Crespo, C., Lautenschlaeger, F., Le Berre, M., Lennon-Dumenil, A. M., Raab, M., Thiam, H. R., Piel, M., Sixt, M., & Voituriez, R. (2015). Actin flows mediate a universal coupling between cell speed and cell persistence. Cell, 161(2), 374-386. https://doi.org/10.1016/j.cell.2015.01.056

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title = "Actin flows mediate a universal coupling between cell speed and cell persistence",

abstract = "Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns.",

author = "Paolo Maiuri and Rupprecht, \{Jean Fran{\c c}ois\} and Stefan Wieser and Verena Ruprecht and Olivier B{\'e}nichou and Nicolas Carpi and Mathieu Coppey and \{De Beco\}, Simon and Nir Gov and Heisenberg, \{Carl Philipp\} and \{Lage Crespo\}, Carolina and Franziska Lautenschlaeger and \{Le Berre\}, Ma{\"e}l and Lennon-Dumenil, \{Ana Maria\} and Matthew Raab and Thiam, \{Hawa Racine\} and Matthieu Piel and Michael Sixt and Rapha{\"e}l Voituriez",

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year = "2015",

month = apr,

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doi = "10.1016/j.cell.2015.01.056",

language = "English",

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Maiuri, P, Rupprecht, JF, Wieser, S, Ruprecht, V, Bénichou, O, Carpi, N, Coppey, M, De Beco, S, Gov, N, Heisenberg, CP, Lage Crespo, C, Lautenschlaeger, F, Le Berre, M, Lennon-Dumenil, AM, Raab, M, Thiam, HR, Piel, M, Sixt, M & Voituriez, R 2015, 'Actin flows mediate a universal coupling between cell speed and cell persistence', Cell, vol. 161, no. 2, pp. 374-386. https://doi.org/10.1016/j.cell.2015.01.056

TY - JOUR

T1 - Actin flows mediate a universal coupling between cell speed and cell persistence

AU - Maiuri, Paolo

AU - Rupprecht, Jean François

AU - Wieser, Stefan

AU - Ruprecht, Verena

AU - Bénichou, Olivier

AU - Carpi, Nicolas

AU - Coppey, Mathieu

AU - De Beco, Simon

AU - Gov, Nir

AU - Heisenberg, Carl Philipp

AU - Lage Crespo, Carolina

AU - Lautenschlaeger, Franziska

AU - Le Berre, Maël

AU - Lennon-Dumenil, Ana Maria

AU - Raab, Matthew

AU - Thiam, Hawa Racine

AU - Piel, Matthieu

AU - Sixt, Michael

AU - Voituriez, Raphaël

PY - 2015/4/9

Y1 - 2015/4/9

N2 - Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns.

AB - Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged so far. Here, we show on the basis of experimental data in vitro and in vivo that cell persistence, which quantifies the straightness of trajectories, is robustly coupled to cell migration speed. We suggest that this universal coupling constitutes a generic law of cell migration, which originates in the advection of polarity cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis relies on a theoretical model that we validate by measuring the persistence of cells upon modulation of actin flow speeds and upon optogenetic manipulation of the binding of an actin regulator to actin filaments. Beyond the quantitative prediction of the coupling, the model yields a generic phase diagram of cellular trajectories, which recapitulates the full range of observed migration patterns.

U2 - 10.1016/j.cell.2015.01.056

DO - 10.1016/j.cell.2015.01.056

M3 - Article

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AN - SCOPUS:84939937425

SN - 0092-8674

VL - 161

SP - 374

EP - 386

JO - Cell

JF - Cell

IS - 2

ER -

Actin flows mediate a universal coupling between cell speed and cell persistence

Abstract

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