Actin lessons from pathogens

Christophe Le Clainche; David G. Drubin

doi:10.1016/S1097-2765(04)00088-7

Actin lessons from pathogens

Christophe Le Clainche
, David G. Drubin

University of California, Berkeley

Research output: Contribution to journal › Review article › peer-review

Abstract

Salmonella typhimurium secretes proteins that co-opt the host actin cytoskeleton to induce membrane ruffling, leading to the uptake of the bacterium. New information about the biochemical activities of the Salmonella protein SipA suggests that this protein might inhibit host cell actin dynamics by competing with ADF/cofilin and gelsolin, two key proteins that promote the turnover of actin filaments.

Original language	English
Pages (from-to)	453-454
Number of pages	2
Journal	Molecular Cell
Volume	13
Issue number	4
DOIs	https://doi.org/10.1016/S1097-2765(04)00088-7
Publication status	Published - 27 Feb 2004
Externally published	Yes

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10.1016/S1097-2765(04)00088-7

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title = "Actin lessons from pathogens",

abstract = "Salmonella typhimurium secretes proteins that co-opt the host actin cytoskeleton to induce membrane ruffling, leading to the uptake of the bacterium. New information about the biochemical activities of the Salmonella protein SipA suggests that this protein might inhibit host cell actin dynamics by competing with ADF/cofilin and gelsolin, two key proteins that promote the turnover of actin filaments.",

author = "\{Le Clainche\}, Christophe and Drubin, \{David G.\}",

year = "2004",

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journal = "Molecular Cell",

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T1 - Actin lessons from pathogens

AU - Le Clainche, Christophe

AU - Drubin, David G.

PY - 2004/2/27

Y1 - 2004/2/27

N2 - Salmonella typhimurium secretes proteins that co-opt the host actin cytoskeleton to induce membrane ruffling, leading to the uptake of the bacterium. New information about the biochemical activities of the Salmonella protein SipA suggests that this protein might inhibit host cell actin dynamics by competing with ADF/cofilin and gelsolin, two key proteins that promote the turnover of actin filaments.

AB - Salmonella typhimurium secretes proteins that co-opt the host actin cytoskeleton to induce membrane ruffling, leading to the uptake of the bacterium. New information about the biochemical activities of the Salmonella protein SipA suggests that this protein might inhibit host cell actin dynamics by competing with ADF/cofilin and gelsolin, two key proteins that promote the turnover of actin filaments.

UR - https://www.scopus.com/pages/publications/1542345484

U2 - 10.1016/S1097-2765(04)00088-7

DO - 10.1016/S1097-2765(04)00088-7

M3 - Review article

C2 - 14992714

AN - SCOPUS:1542345484

SN - 1097-2765

VL - 13

SP - 453

EP - 454

JO - Molecular Cell

JF - Molecular Cell

IS - 4

ER -

Actin lessons from pathogens

Abstract

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