Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution

Benoit Schneider; Philippe Meyer; Simon Sarfati; Laurence Mulard; Catherine Guerreiro; Joëlle Boretto; Joël Janin; Michel Véron; Dominique Deville-Bonne; Bruno Canard

doi:10.1081/NCN-100002300

Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution

Benoit Schneider
, Philippe Meyer
, Simon Sarfati
, Laurence Mulard
, Catherine Guerreiro
, Joëlle Boretto
, Joël Janin
, Michel Véron
, Dominique Deville-Bonne
, Bruno Canard

Institut Pasteur, Paris
CNRS-UPR U. Propre de Recherche 9063
Ecole Superieure Ingenieurs Luminy

Research output: Contribution to journal › Article › peer-review

Abstract

Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH^-₃) or a thio (SH) group on the α-phosphate. Both the α-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of α-borano monophosphate derivatives in terminated viral DNA chain.

Original language	English
Pages (from-to)	297-306
Number of pages	10
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	20
Issue number	4-7
DOIs	https://doi.org/10.1081/NCN-100002300
Publication status	Published - 1 Jan 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1081/NCN-100002300

Cite this

Schneider, B., Meyer, P., Sarfati, S., Mulard, L., Guerreiro, C., Boretto, J., Janin, J., Véron, M., Deville-Bonne, D., & Canard, B. (2001). Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution. Nucleosides, Nucleotides and Nucleic Acids, 20(4-7), 297-306. https://doi.org/10.1081/NCN-100002300

@article{41bff374004f4b5db02b7e2bc2f154f5,

title = "Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution",

abstract = "Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH-3) or a thio (SH) group on the α-phosphate. Both the α-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of α-borano monophosphate derivatives in terminated viral DNA chain.",

author = "Benoit Schneider and Philippe Meyer and Simon Sarfati and Laurence Mulard and Catherine Guerreiro and Jo{\"e}lle Boretto and Jo{\"e}l Janin and Michel V{\'e}ron and Dominique Deville-Bonne and Bruno Canard",

year = "2001",

month = jan,

day = "1",

doi = "10.1081/NCN-100002300",

language = "English",

volume = "20",

pages = "297--306",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

issn = "1525-7770",

number = "4-7",

}

Schneider, B, Meyer, P, Sarfati, S, Mulard, L, Guerreiro, C, Boretto, J, Janin, J, Véron, M, Deville-Bonne, D & Canard, B 2001, 'Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution', Nucleosides, Nucleotides and Nucleic Acids, vol. 20, no. 4-7, pp. 297-306. https://doi.org/10.1081/NCN-100002300

TY - JOUR

T1 - Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase

T2 - Improvement by α-boranophosphate substitution

AU - Schneider, Benoit

AU - Meyer, Philippe

AU - Sarfati, Simon

AU - Mulard, Laurence

AU - Guerreiro, Catherine

AU - Boretto, Joëlle

AU - Janin, Joël

AU - Véron, Michel

AU - Deville-Bonne, Dominique

AU - Canard, Bruno

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH-3) or a thio (SH) group on the α-phosphate. Both the α-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of α-borano monophosphate derivatives in terminated viral DNA chain.

AB - Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH-3) or a thio (SH) group on the α-phosphate. Both the α-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of α-borano monophosphate derivatives in terminated viral DNA chain.

U2 - 10.1081/NCN-100002300

DO - 10.1081/NCN-100002300

M3 - Article

C2 - 11563041

AN - SCOPUS:0034839885

SN - 1525-7770

VL - 20

SP - 297

EP - 306

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 4-7

ER -

Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: Improvement by α-boranophosphate substitution

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this