TY - JOUR
T1 - Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase
T2 - Improvement by α-boranophosphate substitution
AU - Schneider, Benoit
AU - Meyer, Philippe
AU - Sarfati, Simon
AU - Mulard, Laurence
AU - Guerreiro, Catherine
AU - Boretto, Joëlle
AU - Janin, Joël
AU - Véron, Michel
AU - Deville-Bonne, Dominique
AU - Canard, Bruno
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH-3) or a thio (SH) group on the α-phosphate. Both the α-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of α-borano monophosphate derivatives in terminated viral DNA chain.
AB - Nucleoside activation by nucleoside diphosphate kinase and inhibition of HIV-1 reverse transcriptase were studied comparatively for a new class of nucleoside analogs with a borano (BH-3) or a thio (SH) group on the α-phosphate. Both the α-Rp-borano derivatives of AZT and d4T improved phosphorylation by NDP kinase, inhibition of reverse transcription as well as stability of α-borano monophosphate derivatives in terminated viral DNA chain.
U2 - 10.1081/NCN-100002300
DO - 10.1081/NCN-100002300
M3 - Article
C2 - 11563041
AN - SCOPUS:0034839885
SN - 1525-7770
VL - 20
SP - 297
EP - 306
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 4-7
ER -
