Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis

Jennifer Beauvarlet; Jean Louis Mergny; Mojgan Djavaheri-Mergny

doi:10.1080/23723556.2019.1604047

Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis

Jennifer Beauvarlet
, Jean Louis Mergny
, Mojgan Djavaheri-Mergny

Research output: Contribution to journal › Article › peer-review

Abstract

G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.

Original language	English
Article number	1604047
Journal	Molecular and Cellular Oncology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2019.1604047
Publication status	Published - 4 Jul 2019
Externally published	Yes

Keywords

Cancer therapy
DNA damage response
G-quadruplex
autophagy
senescence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2019.1604047

Cite this

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title = "Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis",

abstract = "G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.",

keywords = "Cancer therapy, DNA damage response, G-quadruplex, autophagy, senescence",

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AU - Djavaheri-Mergny, Mojgan

PY - 2019/7/4

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AB - G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.

KW - Cancer therapy

KW - DNA damage response

KW - G-quadruplex

KW - autophagy

KW - senescence

U2 - 10.1080/23723556.2019.1604047

DO - 10.1080/23723556.2019.1604047

M3 - Article

AN - SCOPUS:85065536730

SN - 2372-3556

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ER -

Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis

Abstract

Keywords

UN SDGs

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