Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes

  • Maria Almonacid
  • , Adel Al Jord
  • , Stephany El-Hayek
  • , Alice Othmani
  • , Fanny Coulpier
  • , Sophie Lemoine
  • , Kei Miyamoto
  • , Robert Grosse
  • , Christophe Klein
  • , Tristan Piolot
  • , Philippe Mailly
  • , Raphaël Voituriez
  • , Auguste Genovesio
  • , Marie Hélène Verlhac

Research output: Contribution to journalArticlepeer-review

Abstract

Almonacid et al. show that the positioning of the nucleus in the center of the oocyte is essential for proper gene expression. Actin, which positions the nucleus centrally, also ensures proper nuclear shape, and promotes nuclear envelope and chromatin movements that fine-tune gene expression.

Original languageEnglish
Pages (from-to)145-157.e10
JournalDevelopmental Cell
Volume51
Issue number2
DOIs
Publication statusPublished - 21 Oct 2019

Keywords

  • F-actin
  • bio-physics
  • mechano-transduction
  • mouse oocyte
  • nuclear dynamics

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