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Algebraic identifiability of partial differential equation models

  • Helen M. Byrne
  • , Heather A. Harrington
  • , Alexey Ovchinnikov
  • , Gleb Pogudin
  • , Hamid Rahkooy
  • , Pedro Soto
  • University of Oxford
  • Ludwig Institute for Cancer Research, Oxford
  • Technical University Dresden
  • Centre for Systems Biology Dresden (CSBD)
  • Max Planck Institute of Molecular Cell Biology and Genetics
  • Queens College, City University of New York
  • University of Oxford
  • Virginia Polytechnic Institute and State University

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Differential equation models are crucial to scientific processes across many disciplines, and the values of model parameters are important for analyzing the behaviour of solutions. Identifying these values is known as a parameter estimation, a type of inverse problem, which has applications in areas that include industry, finance and biomedicine. A parameter is called globally identifiable if its value can be uniquely determined from the input and output functions. Checking the global identifiability of model parameters is a useful tool when exploring the well-posedness of a given model. This problem has been intensively studied for ordinary differential equation models, where theory, several efficient algorithms and software packages have been developed. A comprehensive theory for PDEs has hitherto not been developed due to the complexity of initial and boundary conditions. Here, we provide theory and algorithms, based on differential algebra, for testing identifiability of polynomial PDE models. We showcase this approach on PDE models arising in the sciences.

Original languageEnglish
Article number025022
JournalNonlinearity
Volume38
Issue number2
DOIs
Publication statusPublished - 28 Feb 2025

Keywords

  • input-output equations
  • mathematical biology
  • nonlinear PDE models
  • structural parameter identifiability

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