An efficient synthesis of large ring acetylenes

Jean Boivin, Sylvain Huppé, Samir Z. Zard

Research output: Contribution to journalArticlepeer-review

Abstract

The two regioisomeric β-ketoesters obtained by ring expansion of a cycloalkanone with ethyl diazoacetate and a Lewis acid give the same cycloalkyne upon exposure of the corresponding isoxazolinone to sodium nitrite/aqueous acetic acid and ferrous sulfate.

Original languageEnglish
Pages (from-to)5737-5740
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number32
Publication statusPublished - 10 Aug 1995

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