Archaeal DNA Repair

Caroline L’hermitte-Stead; Anaïs Bayard; Alexey Aleksandrov; Roxane Lestini; Hannu Myllykallio

doi:10.1002/9781394372560.ch2

Archaeal DNA Repair

Caroline L’hermitte-Stead, Anaïs Bayard, Alexey Aleksandrov, Roxane Lestini, Hannu Myllykallio

Institut Polytechnique de Paris

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The specific goal of this chapter on archaeal DNA repair is to outline how nature has invented several different strategies, DNA repair pathways, to detect and correct various types of DNA damages. The DNA damage can impact either the single strand or both strands of the DNA duplex. Double-strand breaks may be precisely repaired by homologous recombination, which uses the intact DNA strand as a backup for the correct genetic information (for detailed reviews on archaeal DNA repair). Archaeal DNA polymerases misincorporate ribonucleotides, instead of deoxyribonucleotides, into genomic DNA surprisingly frequently. Many different types of DNA damage either result from errors of DNA replication or halt the replisome. In addition, some archaeal DNA repair proteins such as Fen1 and potentially DNA polymerase PolB are also multitasking between DNA replication and repair.

Original language	English
Title of host publication	Biology of Archaea 2
Subtitle of host publication	Molecular Biology of Archaea, From Genome Maintenance to the Regulation of Gene Expression
Publisher	wiley
Pages	25-44
Number of pages	20
ISBN (Electronic)	9781394372560
ISBN (Print)	9781789451696
DOIs	https://doi.org/10.1002/9781394372560.ch2
Publication status	Published - 1 Jan 2025

Keywords

Archaeal DNA repair
DNA polymerase
Deoxyribonucleotides
Double-strand breaks
Genetic information
Genomic DNA
Ribonucleotides

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10.1002/9781394372560.ch2

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AU - Aleksandrov, Alexey

AU - Lestini, Roxane

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Archaeal DNA Repair

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