Assisted tandem palladium(II)/palladium(0)-catalyzed C-and N-Arylations of quinoxalin-2(1H)-ones in water

Amandine Carrër; Jean Daniel Brion; Mouad Alami; Samir Messaoudi

doi:10.1002/adsc.201400662

Assisted tandem palladium(II)/palladium(0)-catalyzed C-and N-Arylations of quinoxalin-2(1H)-ones in water

Amandine Carrër
, Jean Daniel Brion
, Mouad Alami
, Samir Messaoudi

Univ Paris-Sud
Université Paris-Saclay

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

A straightforward assisted tandem palladium(II)-and palladium(0)-catalyzed direct C-3 and N-4 arylation of quinoxalin-2(1H)-ones with boronic acids and aryl halides in water as safe and cheap solvent is reported. This environmentally friendly catalytic protocol is compatible with a wide range of functional groups and allows construction of various biologically important quinoxalin-2(1H)-one backbones.

Original language	English
Pages (from-to)	3821-3830
Number of pages	10
Journal	Advanced Synthesis and Catalysis
Volume	356
Issue number	18
DOIs	https://doi.org/10.1002/adsc.201400662
Publication status	Published - 15 Dec 2014
Externally published	Yes

Keywords

Assisted tandem catalysis
C-arylation
Narylation
Palladium catalysis
Quinoxalinones

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10.1002/adsc.201400662

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title = "Assisted tandem palladium(II)/palladium(0)-catalyzed C-and N-Arylations of quinoxalin-2(1H)-ones in water",

abstract = "A straightforward assisted tandem palladium(II)-and palladium(0)-catalyzed direct C-3 and N-4 arylation of quinoxalin-2(1H)-ones with boronic acids and aryl halides in water as safe and cheap solvent is reported. This environmentally friendly catalytic protocol is compatible with a wide range of functional groups and allows construction of various biologically important quinoxalin-2(1H)-one backbones.",

keywords = "Assisted tandem catalysis, C-arylation, Narylation, Palladium catalysis, Quinoxalinones",

author = "Amandine Carr{\"e}r and Brion, \{Jean Daniel\} and Mouad Alami and Samir Messaoudi",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley-VCH Verlag GmbH\&Co. KGaA, Weinheim.",

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doi = "10.1002/adsc.201400662",

language = "English",

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T1 - Assisted tandem palladium(II)/palladium(0)-catalyzed C-and N-Arylations of quinoxalin-2(1H)-ones in water

AU - Carrër, Amandine

AU - Brion, Jean Daniel

AU - Alami, Mouad

AU - Messaoudi, Samir

PY - 2014/12/15

Y1 - 2014/12/15

N2 - A straightforward assisted tandem palladium(II)-and palladium(0)-catalyzed direct C-3 and N-4 arylation of quinoxalin-2(1H)-ones with boronic acids and aryl halides in water as safe and cheap solvent is reported. This environmentally friendly catalytic protocol is compatible with a wide range of functional groups and allows construction of various biologically important quinoxalin-2(1H)-one backbones.

AB - A straightforward assisted tandem palladium(II)-and palladium(0)-catalyzed direct C-3 and N-4 arylation of quinoxalin-2(1H)-ones with boronic acids and aryl halides in water as safe and cheap solvent is reported. This environmentally friendly catalytic protocol is compatible with a wide range of functional groups and allows construction of various biologically important quinoxalin-2(1H)-one backbones.

KW - Assisted tandem catalysis

KW - C-arylation

KW - Narylation

KW - Palladium catalysis

KW - Quinoxalinones

U2 - 10.1002/adsc.201400662

DO - 10.1002/adsc.201400662

M3 - Article

AN - SCOPUS:84915745901

SN - 1615-4150

VL - 356

SP - 3821

EP - 3830

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 18

ER -

Assisted tandem palladium(II)/palladium(0)-catalyzed C-and N-Arylations of quinoxalin-2(1H)-ones in water

Abstract

Keywords

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