Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase

Patrizia Alberti; Philippe Schmitt; Chi Hung Nguyen; Christian Rivalle; Magali Hoarau; David S. Grierson; Jean Louis Mergny

doi:10.1016/S0960-894X(02)00080-X

Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase

Patrizia Alberti
, Philippe Schmitt
, Chi Hung Nguyen
, Christian Rivalle
, Magali Hoarau
, David S. Grierson
, Jean Louis Mergny

CNRS/Museum National d'Histoire Naturelle/IRD/UPMC
Centre national de la recherche scientifique

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in T_m value of the G-quadruplex was associated with telomerase inhibition in vitro.

Original language	English
Pages (from-to)	1071-1074
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/S0960-894X(02)00080-X
Publication status	Published - 8 Apr 2002
Externally published	Yes

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10.1016/S0960-894X(02)00080-X

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title = "Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase",

abstract = "Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in Tm value of the G-quadruplex was associated with telomerase inhibition in vitro.",

author = "Patrizia Alberti and Philippe Schmitt and Nguyen, \{Chi Hung\} and Christian Rivalle and Magali Hoarau and \{S. Grierson\}, David and Mergny, \{Jean Louis\}",

note = "Funding Information: We thank P. Mailliet (Aventis, Vitry), J. F. Riou (Reims), M. Mills, L. Guittat, L. Lacroix, P. B. Arimondo and C. H{\'e}l{\`e}ne (MNHN, Paris) for helpful discussions. This work was supported by an ARC grant (no. 4321) and an Aventis research grant (to J.L.M.).",

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doi = "10.1016/S0960-894X(02)00080-X",

language = "English",

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TY - JOUR

T1 - Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase

AU - Alberti, Patrizia

AU - Schmitt, Philippe

AU - Nguyen, Chi Hung

AU - Rivalle, Christian

AU - Hoarau, Magali

AU - S. Grierson, David

AU - Mergny, Jean Louis

N1 - Funding Information: We thank P. Mailliet (Aventis, Vitry), J. F. Riou (Reims), M. Mills, L. Guittat, L. Lacroix, P. B. Arimondo and C. Hélène (MNHN, Paris) for helpful discussions. This work was supported by an ARC grant (no. 4321) and an Aventis research grant (to J.L.M.).

PY - 2002/4/8

Y1 - 2002/4/8

N2 - Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in Tm value of the G-quadruplex was associated with telomerase inhibition in vitro.

AB - Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in Tm value of the G-quadruplex was associated with telomerase inhibition in vitro.

U2 - 10.1016/S0960-894X(02)00080-X

DO - 10.1016/S0960-894X(02)00080-X

M3 - Article

C2 - 11909720

AN - SCOPUS:0037041260

SN - 0960-894X

VL - 12

SP - 1071

EP - 1074

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase

Abstract

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