Biological functions of methyl-CpG-binding proteins

Pierre Antoine Defossez; Irina Stancheva

doi:10.1016/B978-0-12-387685-0.00012-3

Biological functions of methyl-CpG-binding proteins

Pierre Antoine Defossez
, Irina Stancheva

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

DNA methylation is a stable epigenetic mark in plant and vertebrate genomes; it is implicated in regulation of higher order chromatin structure, maintenance of genome integrity, and stable patterns of gene expression. Biological effects of DNA methylation are, at least in part, mediated by proteins that preferentially bind to methylated DNA. It is now recognized that several structurally unrelated protein folds have the ability to recognize methylated CpGs in vitro and in vivo. In this chapter, we focus on the three major families of methyl-CpG-binding proteins: the MBD protein family, Kaiso and Kaiso-like proteins, and SRA domain proteins. We discuss the structural bases of methyl-CpG recognition, the function and specific properties of individual proteins, and their role in human disease such as Rett syndrome and cancer.

Original language	English
Title of host publication	Progress in Molecular Biology and Translational Science
Publisher	Elsevier B.V.
Pages	377-398
Number of pages	22
DOIs	https://doi.org/10.1016/B978-0-12-387685-0.00012-3
Publication status	Published - 1 Jan 2011
Externally published	Yes

Publication series

Name	Progress in Molecular Biology and Translational Science
Volume	101
ISSN (Print)	1877-1173

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chromatin
DNA methylation
Kaiso
MBD
Methyl-CpG
SRA

Access to Document

10.1016/B978-0-12-387685-0.00012-3

Cite this

@inbook{9d459d22cbb243d99d7ba252fd783bc1,

title = "Biological functions of methyl-CpG-binding proteins",

abstract = "DNA methylation is a stable epigenetic mark in plant and vertebrate genomes; it is implicated in regulation of higher order chromatin structure, maintenance of genome integrity, and stable patterns of gene expression. Biological effects of DNA methylation are, at least in part, mediated by proteins that preferentially bind to methylated DNA. It is now recognized that several structurally unrelated protein folds have the ability to recognize methylated CpGs in vitro and in vivo. In this chapter, we focus on the three major families of methyl-CpG-binding proteins: the MBD protein family, Kaiso and Kaiso-like proteins, and SRA domain proteins. We discuss the structural bases of methyl-CpG recognition, the function and specific properties of individual proteins, and their role in human disease such as Rett syndrome and cancer.",

keywords = "Chromatin, DNA methylation, Kaiso, MBD, Methyl-CpG, SRA",

author = "Defossez, \{Pierre Antoine\} and Irina Stancheva",

year = "2011",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-387685-0.00012-3",

language = "English",

series = "Progress in Molecular Biology and Translational Science",

publisher = "Elsevier B.V.",

pages = "377--398",

booktitle = "Progress in Molecular Biology and Translational Science",

}

TY - CHAP

T1 - Biological functions of methyl-CpG-binding proteins

AU - Defossez, Pierre Antoine

AU - Stancheva, Irina

PY - 2011/1/1

Y1 - 2011/1/1

N2 - DNA methylation is a stable epigenetic mark in plant and vertebrate genomes; it is implicated in regulation of higher order chromatin structure, maintenance of genome integrity, and stable patterns of gene expression. Biological effects of DNA methylation are, at least in part, mediated by proteins that preferentially bind to methylated DNA. It is now recognized that several structurally unrelated protein folds have the ability to recognize methylated CpGs in vitro and in vivo. In this chapter, we focus on the three major families of methyl-CpG-binding proteins: the MBD protein family, Kaiso and Kaiso-like proteins, and SRA domain proteins. We discuss the structural bases of methyl-CpG recognition, the function and specific properties of individual proteins, and their role in human disease such as Rett syndrome and cancer.

AB - DNA methylation is a stable epigenetic mark in plant and vertebrate genomes; it is implicated in regulation of higher order chromatin structure, maintenance of genome integrity, and stable patterns of gene expression. Biological effects of DNA methylation are, at least in part, mediated by proteins that preferentially bind to methylated DNA. It is now recognized that several structurally unrelated protein folds have the ability to recognize methylated CpGs in vitro and in vivo. In this chapter, we focus on the three major families of methyl-CpG-binding proteins: the MBD protein family, Kaiso and Kaiso-like proteins, and SRA domain proteins. We discuss the structural bases of methyl-CpG recognition, the function and specific properties of individual proteins, and their role in human disease such as Rett syndrome and cancer.

KW - Chromatin

KW - DNA methylation

KW - Kaiso

KW - MBD

KW - Methyl-CpG

KW - SRA

UR - https://www.scopus.com/pages/publications/79955068902

U2 - 10.1016/B978-0-12-387685-0.00012-3

DO - 10.1016/B978-0-12-387685-0.00012-3

M3 - Chapter

AN - SCOPUS:79955068902

T3 - Progress in Molecular Biology and Translational Science

SP - 377

EP - 398

BT - Progress in Molecular Biology and Translational Science

PB - Elsevier B.V.

ER -

Biological functions of methyl-CpG-binding proteins

Abstract

Publication series

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this