cAMP-Dependent Co-stabilization of Axonal Arbors from Adjacent Developing Neurons

Alice Louail; Martijn C. Sierksma; Antoine Chaffiol; Sarah Baudet; Ahlem Assali; Sandrine Couvet; Melissa Nedjam; Fiona Roche; Yvrick Zagar; Jens Duebel; Xavier Nicol

doi:10.1016/j.celrep.2020.108220

cAMP-Dependent Co-stabilization of Axonal Arbors from Adjacent Developing Neurons

Alice Louail
, Martijn C. Sierksma
, Antoine Chaffiol
, Sarah Baudet
, Ahlem Assali
, Sandrine Couvet
, Melissa Nedjam
, Fiona Roche
, Yvrick Zagar
, Jens Duebel
, Xavier Nicol

École Polytechnique

Sorbonne Université

Research output: Contribution to journal › Article › peer-review

Abstract

The pruning of axonal arbors is critical to refine early exuberant neuronal connections. Theoretical work suggests that co-active axons co-stabilize their connections. Louail et al. provide experimental evidence confirming this predicted cooperation and identify cAMP signaling as a critical pathway for this developmental process.

Original language	English
Article number	108220
Journal	Cell Reports
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2020.108220
Publication status	Published - 6 Oct 2020

Keywords

axon
axonal branches
binocular map
competition
cooperation
dorso-lateral geniculate nucleus
pruning
retina
retinal ganglion cells
spontaneous activity

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10.1016/j.celrep.2020.108220

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title = "cAMP-Dependent Co-stabilization of Axonal Arbors from Adjacent Developing Neurons",

abstract = "The pruning of axonal arbors is critical to refine early exuberant neuronal connections. Theoretical work suggests that co-active axons co-stabilize their connections. Louail et al. provide experimental evidence confirming this predicted cooperation and identify cAMP signaling as a critical pathway for this developmental process.",

keywords = "axon, axonal branches, binocular map, competition, cooperation, dorso-lateral geniculate nucleus, pruning, retina, retinal ganglion cells, spontaneous activity",

author = "Alice Louail and Sierksma, \{Martijn C.\} and Antoine Chaffiol and Sarah Baudet and Ahlem Assali and Sandrine Couvet and Melissa Nedjam and Fiona Roche and Yvrick Zagar and Jens Duebel and Xavier Nicol",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

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doi = "10.1016/j.celrep.2020.108220",

language = "English",

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T1 - cAMP-Dependent Co-stabilization of Axonal Arbors from Adjacent Developing Neurons

AU - Louail, Alice

AU - Sierksma, Martijn C.

AU - Chaffiol, Antoine

AU - Baudet, Sarah

AU - Assali, Ahlem

AU - Couvet, Sandrine

AU - Nedjam, Melissa

AU - Roche, Fiona

AU - Zagar, Yvrick

AU - Duebel, Jens

AU - Nicol, Xavier

PY - 2020/10/6

Y1 - 2020/10/6

N2 - The pruning of axonal arbors is critical to refine early exuberant neuronal connections. Theoretical work suggests that co-active axons co-stabilize their connections. Louail et al. provide experimental evidence confirming this predicted cooperation and identify cAMP signaling as a critical pathway for this developmental process.

AB - The pruning of axonal arbors is critical to refine early exuberant neuronal connections. Theoretical work suggests that co-active axons co-stabilize their connections. Louail et al. provide experimental evidence confirming this predicted cooperation and identify cAMP signaling as a critical pathway for this developmental process.

KW - axon

KW - axonal branches

KW - binocular map

KW - competition

KW - cooperation

KW - dorso-lateral geniculate nucleus

KW - pruning

KW - retina

KW - retinal ganglion cells

KW - spontaneous activity

UR - https://www.scopus.com/pages/publications/85091900140

U2 - 10.1016/j.celrep.2020.108220

DO - 10.1016/j.celrep.2020.108220

M3 - Article

C2 - 33027659

AN - SCOPUS:85091900140

SN - 2211-1247

VL - 33

JO - Cell Reports

JF - Cell Reports

IS - 1

M1 - 108220

ER -

cAMP-Dependent Co-stabilization of Axonal Arbors from Adjacent Developing Neurons

Abstract

Keywords

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