Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

Clélia Mathieu; Samir Messaoudi; Elias Fattal; Juliette Vergnaud-Gauduchon

doi:10.20517/cdr.2019.26

Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

Clélia Mathieu
, Samir Messaoudi
, Elias Fattal
, Juliette Vergnaud-Gauduchon

Research output: Contribution to journal › Review article › peer-review

Abstract

Nanocarriers have been developed in order to protect drugs or to improve drugs efficiency by reaching the damaged tissue and avoiding systemic and local toxicity. By using HSP90 inhibitors, some cancer drug resistances have been overcome and the loading into nanocarriers of such drugs has shown an increase of their activities. This review will present some advantages of HSP90 inhibitors to treat resistant tumors; especially those targeting the mitochondrial protein TRAP1. We will also focus on the targeting of the primary tumors, cancer stem cells and metastatic cells.

Original language	English
Pages (from-to)	381-398
Number of pages	18
Journal	Cancer Drug Resistance
Volume	2
Issue number	3
DOIs	https://doi.org/10.20517/cdr.2019.26
Publication status	Published - 1 Jan 2019
Externally published	Yes

Keywords

Cancer
Heat-shock proteins
Nanoparticles
Resistance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.20517/cdr.2019.26

Cite this

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title = "Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins",

abstract = "Nanocarriers have been developed in order to protect drugs or to improve drugs efficiency by reaching the damaged tissue and avoiding systemic and local toxicity. By using HSP90 inhibitors, some cancer drug resistances have been overcome and the loading into nanocarriers of such drugs has shown an increase of their activities. This review will present some advantages of HSP90 inhibitors to treat resistant tumors; especially those targeting the mitochondrial protein TRAP1. We will also focus on the targeting of the primary tumors, cancer stem cells and metastatic cells.",

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T1 - Cancer drug resistance

T2 - rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

AU - Mathieu, Clélia

AU - Messaoudi, Samir

AU - Fattal, Elias

AU - Vergnaud-Gauduchon, Juliette

N1 - Publisher Copyright: © The Author(s) 2019.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Nanocarriers have been developed in order to protect drugs or to improve drugs efficiency by reaching the damaged tissue and avoiding systemic and local toxicity. By using HSP90 inhibitors, some cancer drug resistances have been overcome and the loading into nanocarriers of such drugs has shown an increase of their activities. This review will present some advantages of HSP90 inhibitors to treat resistant tumors; especially those targeting the mitochondrial protein TRAP1. We will also focus on the targeting of the primary tumors, cancer stem cells and metastatic cells.

AB - Nanocarriers have been developed in order to protect drugs or to improve drugs efficiency by reaching the damaged tissue and avoiding systemic and local toxicity. By using HSP90 inhibitors, some cancer drug resistances have been overcome and the loading into nanocarriers of such drugs has shown an increase of their activities. This review will present some advantages of HSP90 inhibitors to treat resistant tumors; especially those targeting the mitochondrial protein TRAP1. We will also focus on the targeting of the primary tumors, cancer stem cells and metastatic cells.

KW - Cancer

KW - Heat-shock proteins

KW - Nanoparticles

KW - Resistance

U2 - 10.20517/cdr.2019.26

DO - 10.20517/cdr.2019.26

M3 - Review article

AN - SCOPUS:85098761268

SN - 2578-532X

VL - 2

SP - 381

EP - 398

JO - Cancer Drug Resistance

JF - Cancer Drug Resistance

IS - 3

ER -

Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

Abstract

Keywords

UN SDGs

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