Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope

Junha Park; Arvid Lindberg; Jeremy Vizet; Jean Rehbinder; Camille Gennet; Jean Charles Vanel; André Nazac; Elodie Debras; Perrine Capmas; Hervé Fernandez; Angelo Pierangelo

doi:10.1117/12.2526934

Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope

Junha Park
, Arvid Lindberg
, Jeremy Vizet
, Jean Rehbinder
, Camille Gennet
, Jean Charles Vanel
, André Nazac
, Elodie Debras
, Perrine Capmas
, Hervé Fernandez
, Angelo Pierangelo

University Hospital Brugmann
Assistance Publique-Hôpitaux de Paris

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Mueller polarimetric imaging appeared to be very promising to detect the modifications in the microstructure of the uterine cervix due to the development of a precancerous lesion, thus providing very useful information for diagnostics to which practitioner cannot to access with classic color imaging. The first multispectral Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of the uterine cervix will be presented. It has been obtained by miniaturizing a Mueller polarimetric imaging system and "grafting" it on a conventional colposcope, which is a low magnification binocular system, currently used in medical practice to examine the uterine cervix for detection of precancerous lesions. The multispectral MPC enables to obtain reliable Mueller polarimetric images in less than 2 seconds with a spatial resolution of 100 μm simultaneously at 450, 550 and 650 nm. Currently, it is being tested in vivo in the University Hospital of Kremlin Bicêtre in France. In order to evaluate the performance of the technique, polarimetric images need to be compared with histological analyses of biopsies. The procedure developed in collaboration with medical doctors to obtain an accurate correlation between polarimetric images and biopsies will be described.

Original language	English
Title of host publication	Clinical and Preclinical Optical Diagnostics II
Editors	J. Quincy Brown, Ton G. van Leeuwen
Publisher	SPIE
ISBN (Electronic)	9781510628397
DOIs	https://doi.org/10.1117/12.2526934
Publication status	Published - 1 Jan 2019
Event	Clinical and Preclinical Optical Diagnostics II 2019 - Munich, Germany Duration: 23 Jun 2019 → 25 Jun 2019

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11073
ISSN (Print)	1605-7422

Conference

Conference	Clinical and Preclinical Optical Diagnostics II 2019
Country/Territory	Germany
City	Munich
Period	23/06/19 → 25/06/19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cervical cancer
Colposcopy
In-vivo analysis
Mueller polarimetry

Access to Document

10.1117/12.2526934

Cite this

Park, J., Lindberg, A., Vizet, J., Rehbinder, J., Gennet, C., Vanel, J. C., Nazac, A., Debras, E., Capmas, P., Fernandez, H., & Pierangelo, A. (2019). Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope. In J. Q. Brown, & T. G. van Leeuwen (Eds.), Clinical and Preclinical Optical Diagnostics II Article 110730A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073). SPIE. https://doi.org/10.1117/12.2526934

@inproceedings{b729adc110c0491589484be37247fc35,

title = "Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope",

abstract = "Mueller polarimetric imaging appeared to be very promising to detect the modifications in the microstructure of the uterine cervix due to the development of a precancerous lesion, thus providing very useful information for diagnostics to which practitioner cannot to access with classic color imaging. The first multispectral Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of the uterine cervix will be presented. It has been obtained by miniaturizing a Mueller polarimetric imaging system and {"}grafting{"} it on a conventional colposcope, which is a low magnification binocular system, currently used in medical practice to examine the uterine cervix for detection of precancerous lesions. The multispectral MPC enables to obtain reliable Mueller polarimetric images in less than 2 seconds with a spatial resolution of 100 μm simultaneously at 450, 550 and 650 nm. Currently, it is being tested in vivo in the University Hospital of Kremlin Bic{\^e}tre in France. In order to evaluate the performance of the technique, polarimetric images need to be compared with histological analyses of biopsies. The procedure developed in collaboration with medical doctors to obtain an accurate correlation between polarimetric images and biopsies will be described.",

keywords = "Cervical cancer, Colposcopy, In-vivo analysis, Mueller polarimetry",

author = "Junha Park and Arvid Lindberg and Jeremy Vizet and Jean Rehbinder and Camille Gennet and Vanel, \{Jean Charles\} and Andr{\'e} Nazac and Elodie Debras and Perrine Capmas and Herv{\'e} Fernandez and Angelo Pierangelo",

note = "Publisher Copyright: {\textcopyright} 2019 SPIE.; Clinical and Preclinical Optical Diagnostics II 2019 ; Conference date: 23-06-2019 Through 25-06-2019",

year = "2019",

month = jan,

day = "1",

doi = "10.1117/12.2526934",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Brown, \{J. Quincy\} and \{van Leeuwen\}, \{Ton G.\}",

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}

Park, J, Lindberg, A, Vizet, J, Rehbinder, J, Gennet, C, Vanel, JC, Nazac, A, Debras, E, Capmas, P, Fernandez, H & Pierangelo, A 2019, Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope. in JQ Brown & TG van Leeuwen (eds), Clinical and Preclinical Optical Diagnostics II., 110730A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11073, SPIE, Clinical and Preclinical Optical Diagnostics II 2019, Munich, Germany, 23/06/19. https://doi.org/10.1117/12.2526934

Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope. / Park, Junha; Lindberg, Arvid; Vizet, Jeremy et al.
Clinical and Preclinical Optical Diagnostics II. ed. / J. Quincy Brown; Ton G. van Leeuwen. SPIE, 2019. 110730A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope

AU - Park, Junha

AU - Lindberg, Arvid

AU - Vizet, Jeremy

AU - Rehbinder, Jean

AU - Gennet, Camille

AU - Vanel, Jean Charles

AU - Nazac, André

AU - Debras, Elodie

AU - Capmas, Perrine

AU - Fernandez, Hervé

AU - Pierangelo, Angelo

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N2 - Mueller polarimetric imaging appeared to be very promising to detect the modifications in the microstructure of the uterine cervix due to the development of a precancerous lesion, thus providing very useful information for diagnostics to which practitioner cannot to access with classic color imaging. The first multispectral Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of the uterine cervix will be presented. It has been obtained by miniaturizing a Mueller polarimetric imaging system and "grafting" it on a conventional colposcope, which is a low magnification binocular system, currently used in medical practice to examine the uterine cervix for detection of precancerous lesions. The multispectral MPC enables to obtain reliable Mueller polarimetric images in less than 2 seconds with a spatial resolution of 100 μm simultaneously at 450, 550 and 650 nm. Currently, it is being tested in vivo in the University Hospital of Kremlin Bicêtre in France. In order to evaluate the performance of the technique, polarimetric images need to be compared with histological analyses of biopsies. The procedure developed in collaboration with medical doctors to obtain an accurate correlation between polarimetric images and biopsies will be described.

AB - Mueller polarimetric imaging appeared to be very promising to detect the modifications in the microstructure of the uterine cervix due to the development of a precancerous lesion, thus providing very useful information for diagnostics to which practitioner cannot to access with classic color imaging. The first multispectral Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of the uterine cervix will be presented. It has been obtained by miniaturizing a Mueller polarimetric imaging system and "grafting" it on a conventional colposcope, which is a low magnification binocular system, currently used in medical practice to examine the uterine cervix for detection of precancerous lesions. The multispectral MPC enables to obtain reliable Mueller polarimetric images in less than 2 seconds with a spatial resolution of 100 μm simultaneously at 450, 550 and 650 nm. Currently, it is being tested in vivo in the University Hospital of Kremlin Bicêtre in France. In order to evaluate the performance of the technique, polarimetric images need to be compared with histological analyses of biopsies. The procedure developed in collaboration with medical doctors to obtain an accurate correlation between polarimetric images and biopsies will be described.

KW - Cervical cancer

KW - Colposcopy

KW - In-vivo analysis

KW - Mueller polarimetry

U2 - 10.1117/12.2526934

DO - 10.1117/12.2526934

M3 - Conference contribution

AN - SCOPUS:85073723452

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Clinical and Preclinical Optical Diagnostics II

A2 - Brown, J. Quincy

A2 - van Leeuwen, Ton G.

PB - SPIE

T2 - Clinical and Preclinical Optical Diagnostics II 2019

Y2 - 23 June 2019 through 25 June 2019

ER -

Cervical cancer diagnostics with a multispectral Mueller polarimetric colposcope

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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Cite this