CHAPTER 5: High-resolution Magic-angle Spinning (HR-MAS) NMR Spectroscopy

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Since the beginning of high-resolution magic-angle spinning (HR-MAS) NMR spectroscopy in 1990s, we have witnessed tremendous instrumentation and methodological advancements in the HR-MAS NMR technique for semisolids. With HR-MAS, it is now possible to acquire reliable high-quality spectra in a routine and high-throughput fashion, and it has become a well-integrated metabolic screening tool for ex vivo biospecimens such as tissue biopsies, cells and organisms for NMR-based metabolomics research. This chapter provides the basic principles of HR-MAS and describes a few recent noteworthy developments that could strengthen the role of HR-MAS as a frontline NMR technique for metabolomics.

Original languageEnglish
Title of host publicationNew Developments in NMR
EditorsHector C. Keun
PublisherRoyal Society of Chemistry
Pages133-150
Number of pages18
Edition14
ISBN (Electronic)9781782624479, 9781782628545, 9781849736435, 9781849739139
ISBN (Print)9781788010863, 9781788011044
DOIs
Publication statusPublished - 1 Jan 2018
Externally publishedYes

Publication series

NameNew Developments in NMR
Number14
Volume2018-January
ISSN (Print)2044-253X
ISSN (Electronic)2044-2548

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