Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction: Hyperelastic warping

Hua Zou; Xiaodan Zhao; Xi Ce; Lik Chuan Lee; Martin Genet; Yi Su; Rusan Tan; Liang Zhong

doi:10.1109/EMBC.2016.7591640

Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction: Hyperelastic warping

Hua Zou
, Xiaodan Zhao
, Xi Ce
, Lik Chuan Lee
, Martin Genet
, Yi Su
, Rusan Tan
, Liang Zhong

National Heart Centre Singapore
Michigan State University
ASTAR

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Heart failure with preserved ejection fraction (HFPEF) is considered as a major public health problem. Traditionally, HFPEF is diagnosed based on a 'normal' EF, but the studies have explored the potential role of left ventricular mechanics. Furthermore, right ventricular mechanics and bi-ventricular interaction in HFPEF is currently not well understood. In this study, we aim to develop a framework using a hyperelastic warping approach to quantify bi-ventricular and septum strains from cardiac magnetic resonance (CMR) images. Whole heart models were reconstructed in HFPEF, HF with reduced EF (HFREF) and normal control patients, and a Laplace-Dirichlet Rule-Based (LDRB) algorithm was employed to assign circumferential orientation. The LV circumferential strain was 10.56% in normal control, and decreased to 5.90% in HFPEF and 1.66% in HFREF. Interestingly, the RV circumferential strain was 7.29% in normal control, but increased to 8.93% in HFPEF, and decreased to 2.16% in HFREF. The septum circumferential strain was comparable between HFPEF and normal control. Heart failure with preserved ejection fraction demonstrated augmented right ventricular strain and comparable septum strain to maintain its 'normal' ejection fraction. This might unveil a new mechanism of bi-ventricular interaction and compensation in heart failure with preserved ejection fraction.

Original language	English
Title of host publication	2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	4149-4152
Number of pages	4
ISBN (Electronic)	9781457702204
DOIs	https://doi.org/10.1109/EMBC.2016.7591640
Publication status	Published - 13 Oct 2016
Event	38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States Duration: 16 Aug 2016 → 20 Aug 2016

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2016-October
ISSN (Print)	1557-170X

Conference

Conference	38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Country/Territory	United States
City	Orlando
Period	16/08/16 → 20/08/16

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1109/EMBC.2016.7591640

Cite this

Zou, H., Zhao, X., Ce, X., Lee, L. C., Genet, M., Su, Y., Tan, R., & Zhong, L. (2016). Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction: Hyperelastic warping. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 (pp. 4149-4152). Article 7591640 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2016-October). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2016.7591640

Zou, Hua ; Zhao, Xiaodan ; Ce, Xi et al. / Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction : Hyperelastic warping. 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 4149-4152 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

@inproceedings{1062b43d37664599882e8eee26bd481e,

title = "Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction: Hyperelastic warping",

abstract = "Heart failure with preserved ejection fraction (HFPEF) is considered as a major public health problem. Traditionally, HFPEF is diagnosed based on a 'normal' EF, but the studies have explored the potential role of left ventricular mechanics. Furthermore, right ventricular mechanics and bi-ventricular interaction in HFPEF is currently not well understood. In this study, we aim to develop a framework using a hyperelastic warping approach to quantify bi-ventricular and septum strains from cardiac magnetic resonance (CMR) images. Whole heart models were reconstructed in HFPEF, HF with reduced EF (HFREF) and normal control patients, and a Laplace-Dirichlet Rule-Based (LDRB) algorithm was employed to assign circumferential orientation. The LV circumferential strain was 10.56\% in normal control, and decreased to 5.90\% in HFPEF and 1.66\% in HFREF. Interestingly, the RV circumferential strain was 7.29\% in normal control, but increased to 8.93\% in HFPEF, and decreased to 2.16\% in HFREF. The septum circumferential strain was comparable between HFPEF and normal control. Heart failure with preserved ejection fraction demonstrated augmented right ventricular strain and comparable septum strain to maintain its 'normal' ejection fraction. This might unveil a new mechanism of bi-ventricular interaction and compensation in heart failure with preserved ejection fraction.",

author = "Hua Zou and Xiaodan Zhao and Xi Ce and Lee, \{Lik Chuan\} and Martin Genet and Yi Su and Rusan Tan and Liang Zhong",

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Zou, H, Zhao, X, Ce, X, Lee, LC, Genet, M, Su, Y, Tan, R & Zhong, L 2016, Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction: Hyperelastic warping. in 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016., 7591640, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2016-October, Institute of Electrical and Electronics Engineers Inc., pp. 4149-4152, 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, United States, 16/08/16. https://doi.org/10.1109/EMBC.2016.7591640

Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction: Hyperelastic warping. / Zou, Hua; Zhao, Xiaodan; Ce, Xi et al.
2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc., 2016. p. 4149-4152 7591640 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2016-October).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction

T2 - 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016

AU - Zou, Hua

AU - Zhao, Xiaodan

AU - Ce, Xi

AU - Lee, Lik Chuan

AU - Genet, Martin

AU - Su, Yi

AU - Tan, Rusan

AU - Zhong, Liang

PY - 2016/10/13

Y1 - 2016/10/13

N2 - Heart failure with preserved ejection fraction (HFPEF) is considered as a major public health problem. Traditionally, HFPEF is diagnosed based on a 'normal' EF, but the studies have explored the potential role of left ventricular mechanics. Furthermore, right ventricular mechanics and bi-ventricular interaction in HFPEF is currently not well understood. In this study, we aim to develop a framework using a hyperelastic warping approach to quantify bi-ventricular and septum strains from cardiac magnetic resonance (CMR) images. Whole heart models were reconstructed in HFPEF, HF with reduced EF (HFREF) and normal control patients, and a Laplace-Dirichlet Rule-Based (LDRB) algorithm was employed to assign circumferential orientation. The LV circumferential strain was 10.56% in normal control, and decreased to 5.90% in HFPEF and 1.66% in HFREF. Interestingly, the RV circumferential strain was 7.29% in normal control, but increased to 8.93% in HFPEF, and decreased to 2.16% in HFREF. The septum circumferential strain was comparable between HFPEF and normal control. Heart failure with preserved ejection fraction demonstrated augmented right ventricular strain and comparable septum strain to maintain its 'normal' ejection fraction. This might unveil a new mechanism of bi-ventricular interaction and compensation in heart failure with preserved ejection fraction.

AB - Heart failure with preserved ejection fraction (HFPEF) is considered as a major public health problem. Traditionally, HFPEF is diagnosed based on a 'normal' EF, but the studies have explored the potential role of left ventricular mechanics. Furthermore, right ventricular mechanics and bi-ventricular interaction in HFPEF is currently not well understood. In this study, we aim to develop a framework using a hyperelastic warping approach to quantify bi-ventricular and septum strains from cardiac magnetic resonance (CMR) images. Whole heart models were reconstructed in HFPEF, HF with reduced EF (HFREF) and normal control patients, and a Laplace-Dirichlet Rule-Based (LDRB) algorithm was employed to assign circumferential orientation. The LV circumferential strain was 10.56% in normal control, and decreased to 5.90% in HFPEF and 1.66% in HFREF. Interestingly, the RV circumferential strain was 7.29% in normal control, but increased to 8.93% in HFPEF, and decreased to 2.16% in HFREF. The septum circumferential strain was comparable between HFPEF and normal control. Heart failure with preserved ejection fraction demonstrated augmented right ventricular strain and comparable septum strain to maintain its 'normal' ejection fraction. This might unveil a new mechanism of bi-ventricular interaction and compensation in heart failure with preserved ejection fraction.

U2 - 10.1109/EMBC.2016.7591640

DO - 10.1109/EMBC.2016.7591640

M3 - Conference contribution

C2 - 28269196

AN - SCOPUS:85009074441

T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

SP - 4149

EP - 4152

BT - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016

PB - Institute of Electrical and Electronics Engineers Inc.

Y2 - 16 August 2016 through 20 August 2016

ER -

Zou H, Zhao X, Ce X, Lee LC, Genet M, Su Y et al. Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction: Hyperelastic warping. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Institute of Electrical and Electronics Engineers Inc. 2016. p. 4149-4152. 7591640. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2016.7591640

Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction: Hyperelastic warping

Abstract

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