TY - GEN
T1 - Characterization of patient-specific biventricular mechanics in heart failure with preserved ejection fraction
T2 - 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
AU - Zou, Hua
AU - Zhao, Xiaodan
AU - Ce, Xi
AU - Lee, Lik Chuan
AU - Genet, Martin
AU - Su, Yi
AU - Tan, Rusan
AU - Zhong, Liang
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/10/13
Y1 - 2016/10/13
N2 - Heart failure with preserved ejection fraction (HFPEF) is considered as a major public health problem. Traditionally, HFPEF is diagnosed based on a 'normal' EF, but the studies have explored the potential role of left ventricular mechanics. Furthermore, right ventricular mechanics and bi-ventricular interaction in HFPEF is currently not well understood. In this study, we aim to develop a framework using a hyperelastic warping approach to quantify bi-ventricular and septum strains from cardiac magnetic resonance (CMR) images. Whole heart models were reconstructed in HFPEF, HF with reduced EF (HFREF) and normal control patients, and a Laplace-Dirichlet Rule-Based (LDRB) algorithm was employed to assign circumferential orientation. The LV circumferential strain was 10.56% in normal control, and decreased to 5.90% in HFPEF and 1.66% in HFREF. Interestingly, the RV circumferential strain was 7.29% in normal control, but increased to 8.93% in HFPEF, and decreased to 2.16% in HFREF. The septum circumferential strain was comparable between HFPEF and normal control. Heart failure with preserved ejection fraction demonstrated augmented right ventricular strain and comparable septum strain to maintain its 'normal' ejection fraction. This might unveil a new mechanism of bi-ventricular interaction and compensation in heart failure with preserved ejection fraction.
AB - Heart failure with preserved ejection fraction (HFPEF) is considered as a major public health problem. Traditionally, HFPEF is diagnosed based on a 'normal' EF, but the studies have explored the potential role of left ventricular mechanics. Furthermore, right ventricular mechanics and bi-ventricular interaction in HFPEF is currently not well understood. In this study, we aim to develop a framework using a hyperelastic warping approach to quantify bi-ventricular and septum strains from cardiac magnetic resonance (CMR) images. Whole heart models were reconstructed in HFPEF, HF with reduced EF (HFREF) and normal control patients, and a Laplace-Dirichlet Rule-Based (LDRB) algorithm was employed to assign circumferential orientation. The LV circumferential strain was 10.56% in normal control, and decreased to 5.90% in HFPEF and 1.66% in HFREF. Interestingly, the RV circumferential strain was 7.29% in normal control, but increased to 8.93% in HFPEF, and decreased to 2.16% in HFREF. The septum circumferential strain was comparable between HFPEF and normal control. Heart failure with preserved ejection fraction demonstrated augmented right ventricular strain and comparable septum strain to maintain its 'normal' ejection fraction. This might unveil a new mechanism of bi-ventricular interaction and compensation in heart failure with preserved ejection fraction.
U2 - 10.1109/EMBC.2016.7591640
DO - 10.1109/EMBC.2016.7591640
M3 - Conference contribution
C2 - 28269196
AN - SCOPUS:85009074441
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 4149
EP - 4152
BT - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 16 August 2016 through 20 August 2016
ER -
