Chemoselective Reduction: Xanthates as Traceless Precursors of Polyfunctionalized α,α-Dichloroketones

Lucile Anthore-Dalion; Samir Z. Zard

doi:10.1021/acs.orglett.7b02636

Chemoselective Reduction: Xanthates as Traceless Precursors of Polyfunctionalized α,α-Dichloroketones

Lucile Anthore-Dalion
, Samir Z. Zard

Laboratoire de Synthèse Organique

Research output: Contribution to journal › Article › peer-review

Abstract

The use of BEt₃·H₂O has allowed the chemoselective reductive dexanthylation in the presence of the very fragile α,α-dichloroketone motif. This has solved a major hurdle in our approach to this important, but hitherto grossly understudied, family of compounds and opened access to a number of very useful synthetic transformations.

Original language	English
Pages (from-to)	5545-5548
Number of pages	4
Journal	Organic Letters
Volume	19
Issue number	20
DOIs	https://doi.org/10.1021/acs.orglett.7b02636
Publication status	Published - 20 Oct 2017
Externally published	Yes

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title = "Chemoselective Reduction: Xanthates as Traceless Precursors of Polyfunctionalized α,α-Dichloroketones",

abstract = "The use of BEt3·H2O has allowed the chemoselective reductive dexanthylation in the presence of the very fragile α,α-dichloroketone motif. This has solved a major hurdle in our approach to this important, but hitherto grossly understudied, family of compounds and opened access to a number of very useful synthetic transformations.",

author = "Lucile Anthore-Dalion and Zard, \{Samir Z.\}",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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doi = "10.1021/acs.orglett.7b02636",

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T2 - Xanthates as Traceless Precursors of Polyfunctionalized α,α-Dichloroketones

AU - Anthore-Dalion, Lucile

AU - Zard, Samir Z.

PY - 2017/10/20

Y1 - 2017/10/20

N2 - The use of BEt3·H2O has allowed the chemoselective reductive dexanthylation in the presence of the very fragile α,α-dichloroketone motif. This has solved a major hurdle in our approach to this important, but hitherto grossly understudied, family of compounds and opened access to a number of very useful synthetic transformations.

AB - The use of BEt3·H2O has allowed the chemoselective reductive dexanthylation in the presence of the very fragile α,α-dichloroketone motif. This has solved a major hurdle in our approach to this important, but hitherto grossly understudied, family of compounds and opened access to a number of very useful synthetic transformations.

U2 - 10.1021/acs.orglett.7b02636

DO - 10.1021/acs.orglett.7b02636

M3 - Article

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AN - SCOPUS:85031807809

SN - 1523-7060

VL - 19

SP - 5545

EP - 5548

JO - Organic Letters

JF - Organic Letters

IS - 20

ER -

Chemoselective Reduction: Xanthates as Traceless Precursors of Polyfunctionalized α,α-Dichloroketones

Abstract

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