TY - JOUR
T1 - Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients
AU - Leleu, Igor
AU - Jhanji, Vishal
AU - Touhami, Sara
AU - Westcott, Mark
AU - Angi, Martina
AU - Titah, Cherif
AU - Rousseau, Antoine
AU - Hamard, Pascale
AU - Brasnu, Emmanuelle
AU - Manicom, Thomas
AU - Blumen-Ohana, Esther
AU - Rozenberg, Flore
AU - Vauloup-Fellous, Christelle
AU - Deback, Claire
AU - Labetoulle, Marc
AU - Sahel, Jose Alain
AU - Bodaghi, Bahram
AU - Merabet, Lilia
AU - Kobal, Alfred
AU - Brignole-Baudouin, Françoise
AU - Errera, Marie Hélène
N1 - Publisher Copyright:
© 2019 Taylor & Francis Group, LLC.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Objective: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin. Material and Methods: Multicenter retrospective study of 38 patients with at least one test, either HCMV-positive PCR or GWc. Results: Features of Posner-Schlossman syndrome were observed in 50% of the eyes, Fuchs heterochromic iridocyclitis in 13% of the eyes, chronic nonspecific anterior uveitis in 21% of the eyes, and corneal endotheliitis in 18% of the eyes. PCR and GWc were positive for HCMV in 50% and 96.2% of the eyes, respectively. Glaucoma was diagnosed in 50% of eyes. Treatment was oral valganciclovir in about half of the patients. Other treatments were intravenous ganciclovir and/or ganciclovir topical ointment and/or intravitreal ganciclovir. Conclusions: No obvious association of specific clinical features with individual ethnicity could be identified. We found a high rate of glaucoma in all ethnic groups. There was a delay in diagnosis and specific treatment of HCMV in most patients.
AB - Objective: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin. Material and Methods: Multicenter retrospective study of 38 patients with at least one test, either HCMV-positive PCR or GWc. Results: Features of Posner-Schlossman syndrome were observed in 50% of the eyes, Fuchs heterochromic iridocyclitis in 13% of the eyes, chronic nonspecific anterior uveitis in 21% of the eyes, and corneal endotheliitis in 18% of the eyes. PCR and GWc were positive for HCMV in 50% and 96.2% of the eyes, respectively. Glaucoma was diagnosed in 50% of eyes. Treatment was oral valganciclovir in about half of the patients. Other treatments were intravenous ganciclovir and/or ganciclovir topical ointment and/or intravitreal ganciclovir. Conclusions: No obvious association of specific clinical features with individual ethnicity could be identified. We found a high rate of glaucoma in all ethnic groups. There was a delay in diagnosis and specific treatment of HCMV in most patients.
KW - Fuchs heterochromic iridocyclitis
KW - Goldmann-Witmer coefficient
KW - HCMV
KW - Posner-Schlossman syndrome
KW - endotheliitis
KW - polymerase chain reaction
KW - uveitis
U2 - 10.1080/09273948.2019.1662059
DO - 10.1080/09273948.2019.1662059
M3 - Article
C2 - 31642720
AN - SCOPUS:85074473152
SN - 0927-3948
VL - 29
SP - 160
EP - 168
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 1
ER -