Cluster Tof-Sims imaging as a tool for micrometric histology of lipids in tissue

Claudia Bich, David Touboul, Alain Brunelle

Research output: Contribution to journalArticlepeer-review

Abstract

Recent developments in instrumentation, ion beams or analyzers, for cluster time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging are described here. The methods which are employed to increase the sensitivity or to perform threedimensional analyses in the organic materials are also illustrated. This review shows the improvements made for lipid imaging by cluster TOF-SIMS in various types of material and applications, and gives reasons for the expansion of its utilization.

Original languageEnglish
Pages (from-to)442-451
Number of pages10
JournalMass Spectrometry Reviews
Volume33
Issue number6
DOIs
Publication statusPublished - 1 Nov 2014

Keywords

  • Clusters
  • Lipids
  • Mass spectrometry imaging
  • TOF-SIMS

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