Cobalt Bromide-Catalyzed Negishi-Type Cross-Coupling of Amides

Céline Dorval; Oleh Stetsiuk; Sylvaine Gaillard; Elodie Dubois; Corinne Gosmini; Grégory Danoun

doi:10.1021/acs.orglett.2c00940

Cobalt Bromide-Catalyzed Negishi-Type Cross-Coupling of Amides

Céline Dorval, Oleh Stetsiuk, Sylvaine Gaillard, Elodie Dubois, Corinne Gosmini, Grégory Danoun

Research output: Contribution to journal › Article › peer-review

Abstract

Herein, we describe a novel Negishi-type cross-coupling of amides employing only cobalt bromide salt as the catalyst. This original reaction is highly tolerant to various glutarimide amides as well as organozinc coupling partners. These conditions also allow the performance of the cross-coupling reaction in an eco-compatible solvent such as ethyl acetate on a large scale.

Original language	English
Pages (from-to)	2778-2782
Number of pages	5
Journal	Organic Letters
Volume	24
Issue number	14
DOIs	https://doi.org/10.1021/acs.orglett.2c00940
Publication status	Published - 15 Apr 2022

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title = "Cobalt Bromide-Catalyzed Negishi-Type Cross-Coupling of Amides",

abstract = "Herein, we describe a novel Negishi-type cross-coupling of amides employing only cobalt bromide salt as the catalyst. This original reaction is highly tolerant to various glutarimide amides as well as organozinc coupling partners. These conditions also allow the performance of the cross-coupling reaction in an eco-compatible solvent such as ethyl acetate on a large scale.",

author = "C{\'e}line Dorval and Oleh Stetsiuk and Sylvaine Gaillard and Elodie Dubois and Corinne Gosmini and Gr{\'e}gory Danoun",

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T1 - Cobalt Bromide-Catalyzed Negishi-Type Cross-Coupling of Amides

AU - Dorval, Céline

AU - Stetsiuk, Oleh

AU - Gaillard, Sylvaine

AU - Dubois, Elodie

AU - Gosmini, Corinne

AU - Danoun, Grégory

PY - 2022/4/15

Y1 - 2022/4/15

N2 - Herein, we describe a novel Negishi-type cross-coupling of amides employing only cobalt bromide salt as the catalyst. This original reaction is highly tolerant to various glutarimide amides as well as organozinc coupling partners. These conditions also allow the performance of the cross-coupling reaction in an eco-compatible solvent such as ethyl acetate on a large scale.

AB - Herein, we describe a novel Negishi-type cross-coupling of amides employing only cobalt bromide salt as the catalyst. This original reaction is highly tolerant to various glutarimide amides as well as organozinc coupling partners. These conditions also allow the performance of the cross-coupling reaction in an eco-compatible solvent such as ethyl acetate on a large scale.

U2 - 10.1021/acs.orglett.2c00940

DO - 10.1021/acs.orglett.2c00940

M3 - Article

C2 - 35380446

AN - SCOPUS:85128489335

SN - 1523-7060

VL - 24

SP - 2778

EP - 2782

JO - Organic Letters

JF - Organic Letters

IS - 14

ER -

Cobalt Bromide-Catalyzed Negishi-Type Cross-Coupling of Amides

Abstract

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