Cobalt-Catalyzed Carbozincation of Ynamides

Romain Sallio; Martin Corpet; Loic Habert; Muriel Durandetti; Corinne Gosmini; Isabelle Gillaizeau

doi:10.1021/acs.joc.6b02612

Cobalt-Catalyzed Carbozincation of Ynamides

Romain Sallio
, Martin Corpet
, Loic Habert
, Muriel Durandetti
, Corinne Gosmini
, Isabelle Gillaizeau

conventionnée avec l'Université d'Orléans
Université Paris-Saclay
Normandie Université

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

An original cobalt-catalyzed ynamide carbozincation leading mainly to diverse 3-aryl enamides with mild reaction conditions and good functional-group tolerance has been developed. This reaction displays an excellent regio- and total stereoselectivity and opens the way to appealing synthetic applications. Moreover, this approach allows the selective synthesis of biologically relevant 3,5-disubstituted oxazolone frameworks.

Original language	English
Pages (from-to)	1254-1259
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	82
Issue number	2
DOIs	https://doi.org/10.1021/acs.joc.6b02612
Publication status	Published - 20 Jan 2017
Externally published	Yes

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10.1021/acs.joc.6b02612

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title = "Cobalt-Catalyzed Carbozincation of Ynamides",

abstract = "An original cobalt-catalyzed ynamide carbozincation leading mainly to diverse 3-aryl enamides with mild reaction conditions and good functional-group tolerance has been developed. This reaction displays an excellent regio- and total stereoselectivity and opens the way to appealing synthetic applications. Moreover, this approach allows the selective synthesis of biologically relevant 3,5-disubstituted oxazolone frameworks.",

author = "Romain Sallio and Martin Corpet and Loic Habert and Muriel Durandetti and Corinne Gosmini and Isabelle Gillaizeau",

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AU - Sallio, Romain

AU - Corpet, Martin

AU - Habert, Loic

AU - Durandetti, Muriel

AU - Gosmini, Corinne

AU - Gillaizeau, Isabelle

PY - 2017/1/20

Y1 - 2017/1/20

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AB - An original cobalt-catalyzed ynamide carbozincation leading mainly to diverse 3-aryl enamides with mild reaction conditions and good functional-group tolerance has been developed. This reaction displays an excellent regio- and total stereoselectivity and opens the way to appealing synthetic applications. Moreover, this approach allows the selective synthesis of biologically relevant 3,5-disubstituted oxazolone frameworks.

U2 - 10.1021/acs.joc.6b02612

DO - 10.1021/acs.joc.6b02612

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EP - 1259

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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Cobalt-Catalyzed Carbozincation of Ynamides

Abstract

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