Complete Mueller polarimetry: Do we need it for biological tissues diagnosis?

  • Tatiana Novikova
  • , Jessica C. Ramella-Roman
  • , Leonard Felger
  • , Romain Gros
  • , Ekkehard Hewer
  • , Theoni Maragkou
  • , Richard McKinley
  • , Stefano Moriconi
  • , Michael Murek
  • , Angelo Pierangelo
  • , Omar Rodríguez-Núñez
  • , Irena Zubak
  • , Philippe Schucht

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The advent of polarization-sensitive cameras opens the avenue for real-time in-vivo polarimetric diagnostic imaging of biological tissues in clinical settings, but this approach allows measuring only the first three rows of 4×4 Mueller matrix. In order to extract diagnostically relevant images of tissue linear retardance, azimuth of the optical axis and depolarization from the partial Mueller matrix we have formulated a theoretical framework for the decomposition of 3×4 Mueller matrices and tested its validity on both simulated data for optical phantoms and experimental data collected from thick sections of formalin-fixed human brain measured in reflection. The polarimetric maps calculated with our algorithm and Lu-Chipman polar decomposition of the complete Mueller matrices demonstrate compelling correlation and preserve diagnostic image contrast.

Original languageEnglish
Title of host publicationPolarization Science and Remote Sensing XI
EditorsMeredith K. Kupinski, Joseph A. Shaw, Frans Snik
PublisherSPIE
ISBN (Electronic)9781510665941
DOIs
Publication statusPublished - 1 Jan 2023
EventPolarization Science and Remote Sensing XI 2023 - San Diego, United States
Duration: 21 Aug 202322 Aug 2023

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume12690
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferencePolarization Science and Remote Sensing XI 2023
Country/TerritoryUnited States
CitySan Diego
Period21/08/2322/08/23

Keywords

  • Partial Mueller polarimetry
  • birefringence
  • depolarization
  • polarimetric imaging of tissue

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