TY - GEN
T1 - Compositional modelling of signalling pathways in timed concurrent constraint programming
AU - Chiarugi, Davide
AU - Falaschi, Moreno
AU - Olarte, Carlos
AU - Palamidessi, Catuscia
PY - 2010/10/25
Y1 - 2010/10/25
N2 - The biological data regarding the signalling pathways often consider single pathways or a small number of them. We propose a methodology for composing this kind of data in a coherent framework, in order to be able to investigate a bigger number of signalling pathways. We specify a biological system by means of a set of stoichiometric-like equations resembling the essential features of molecular interactions. We represent these equations by a timed concurrent constraint (ntcc) language, which can deal with partial information and the time for a reaction to occur. We describe a freely available prototypical implementation of our framework.
AB - The biological data regarding the signalling pathways often consider single pathways or a small number of them. We propose a methodology for composing this kind of data in a coherent framework, in order to be able to investigate a bigger number of signalling pathways. We specify a biological system by means of a set of stoichiometric-like equations resembling the essential features of molecular interactions. We represent these equations by a timed concurrent constraint (ntcc) language, which can deal with partial information and the time for a reaction to occur. We describe a freely available prototypical implementation of our framework.
U2 - 10.1145/1854776.1854843
DO - 10.1145/1854776.1854843
M3 - Conference contribution
AN - SCOPUS:77958068688
SN - 9781450304382
T3 - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
SP - 414
EP - 417
BT - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
T2 - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
Y2 - 2 August 2010 through 4 August 2010
ER -