Copper-Catalyzed Sonogashira Reaction in Water

  • Yujia Liu
  • , Vincent Blanchard
  • , Grégory Danoun
  • , Zhaoyang Zhang
  • , Anis Tlili
  • , Wenlong Zhang
  • , Florian Monnier
  • , Arie Van Der Lee
  • , Jincheng Mao
  • , Marc Taillefer

Research output: Contribution to journalArticlepeer-review

Abstract

Copper-catalyzed Sonogashira reaction has been realized under biphasic conditions (water / organic substrates) allowing decreasing the copper loading up to 0.02–0.2 mol %. A potential intermediate species of the reaction, corresponding to a copper cluster linked with acetylide moiety, has been identified.

Original languageEnglish
Pages (from-to)11599-11602
Number of pages4
JournalChemistrySelect
Volume2
Issue number35
DOIs
Publication statusPublished - 11 Dec 2017
Externally publishedYes

Keywords

  • Sonogashira
  • copper-catalyzed
  • mechanism
  • turn-over
  • water

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