Abstract
The structure of the Fab-staphylococcus aureus protein A (SpA) and Fab-peptostreptococcus magnus protein L (PpL) complexes was studied which was applied to a few ternary complexes. The use of Ig-biding proteins as a way of extending the method from HIV gp120 to all proteins for which there are monoclonal antibodies was also proposed. It was found that even with relatively unpurified samples, it was possible to discover crystallization. The results showed that Ig-binding proteins can positively influence the crystallization of Fab-antigen complexes.
| Original language | English |
|---|---|
| Pages (from-to) | 573-579 |
| Number of pages | 7 |
| Journal | Journal of Crystal Growth |
| Volume | 232 |
| Issue number | 1-4 |
| DOIs | |
| Publication status | Published - 1 Nov 2001 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- A1. biocrystallization
- A1. screening
- B1. antibodies
- B1. biological macromolecules
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