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Diagnostics of high grade cervical intraepithelial neoplasia with Mueller matrix polarimetry

  • Université Paris-Saclay
  • University of Arizona
  • Université Paris-Sud

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

An enhancement of contrast between healthy and neoplastic zones in Mueller matrix images of excised cervical tissue was demonstrated in our prior work for the visible wavelength range. In this paper we present the statistical analysis of Mueller polarimetric data for the diagnostics of high grade cervical intraepithelial neoplasia. The results of linear and non-linear post-processing compressions of the full Mueller matrix are discussed and compared in terms of diagnostic performance. The final goal of these studies is to estimate and compare the diagnostic usefulness of 16 polarimetric measurements required for the reconstruction of complete Mueller matrix of a sample, while looking for an optimal design of future imaging protocols.

Original languageEnglish
Title of host publicationNovel Biophotonics Techniques and Applications V
EditorsArjen Amelink, Seemantini K. Nadkarni
PublisherSPIE
ISBN (Electronic)9781510628434
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes
EventNovel Biophotonics Techniques and Applications V 2019 - Munich, Germany
Duration: 26 Jun 201927 Jun 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11075
ISSN (Print)1605-7422

Conference

ConferenceNovel Biophotonics Techniques and Applications V 2019
Country/TerritoryGermany
CityMunich
Period26/06/1927/06/19

Keywords

  • Mueller matrix imaging
  • cervical intraepithelial neoplasia
  • optical biopsy
  • postprocessing of polarimetric data
  • statistical analysis

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