Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

Nicolas Debons; Dounia Dems; Christophe Hélary; Sylvain Le Grill; Lise Picaut; Flore Renaud; Nicolas Delsuc; Marie Claire Schanne-Klein; Thibaud Coradin; Carole Aimé

doi:10.1039/c9bm01029g

Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

Nicolas Debons
, Dounia Dems
, Christophe Hélary
, Sylvain Le Grill
, Lise Picaut
, Flore Renaud
, Nicolas Delsuc
, Marie Claire Schanne-Klein
, Thibaud Coradin
, Carole Aimé

Sorbonne Université
Gustave Roussy Comprehensive Cancer Institute
PSL research University & IPSL

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.

Original language	English
Pages (from-to)	569-576
Number of pages	8
Journal	Biomaterials Science
Volume	8
Issue number	2
DOIs	https://doi.org/10.1039/c9bm01029g
Publication status	Published - 21 Jan 2020

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10.1039/c9bm01029g

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title = "Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites",

abstract = "Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.",

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AU - Debons, Nicolas

AU - Dems, Dounia

AU - Hélary, Christophe

AU - Le Grill, Sylvain

AU - Picaut, Lise

AU - Renaud, Flore

AU - Delsuc, Nicolas

AU - Schanne-Klein, Marie Claire

AU - Coradin, Thibaud

AU - Aimé, Carole

PY - 2020/1/21

Y1 - 2020/1/21

N2 - Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.

AB - Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.

U2 - 10.1039/c9bm01029g

DO - 10.1039/c9bm01029g

M3 - Article

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AN - SCOPUS:85078374576

SN - 2047-4830

VL - 8

SP - 569

EP - 576

JO - Biomaterials Science

JF - Biomaterials Science

IS - 2

ER -

Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

Abstract

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