Diffusion Across Semi-permeable Barriers: Spectral Properties, Efficient Computation, and Applications

We present an efficient method to compute the eigenvalues and eigenmodes of the diffusion operator ∇ (D∇) on one-dimensional heterogeneous structures with multiple semi-permeable barriers. This method allows us to calculate the diffusion propagator and related quantities such as diffusion MRI signal or first exit time distribution analytically for regular geometries and numerically for arbitrary ones. The effect of the barriers and the transition from infinite permeability (no barriers) to zero permeability (impermeable barriers) are investigated.