DIFLUORPHOS and SYNPHOS in asymmetric catalysis: Synthetic applications

Sebastien Prevost, Tahar Ayad, Jean Pierre Genet, Phannarath Phansavath, Virginie Ratovelomanana-Vidal

Research output: Contribution to journalArticlepeer-review

Abstract

Enantiomerically pure diphosphines play an important role in various homogeneous metalcatalyzed asymmetric reactions. Over the last few years, our group has been involved in the design and synthesis of atropisomeric ligands named SYNPHOS and DIFLUORPHOS with complementary stereoelectronic properties. This paper shows the high catalytic performances of DIFLUORPHOS, SYNPHOS and SYNPHOS analogues for some C-H and C-C bond forming processes as well as for the synthesis of biorelevant targets.

Original languageEnglish
Pages (from-to)325-340
Number of pages16
JournalJournal of Chemical Sciences
Volume126
Issue number2
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Hydrogenation
  • asymmetric catalysis
  • atropisomeric phosphines
  • total synthesis

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