Abstract
No activation needed: The first efficient method for direct α-arylation of non-activated or non-protected family of enolizable ketones with simple aryl iodides employs a catalytic copper system. The method shows potential for the easy and step-economical synthesis of tamoxifen, the most commonly administrated drug for the management of breast cancer. R, R′, R′′ = electron-donating or electron-withdrawing groups.
| Original language | English |
|---|---|
| Pages (from-to) | 12815-12819 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 51 |
| Issue number | 51 |
| DOIs | |
| Publication status | Published - 14 Dec 2012 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- arenes
- copper
- homogeneous catalysis
- ketones
- synthetic methods
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