Directed migration of cells in contact with anisotropic microstructures

  • Maël Le Berre
  • , Yan Jun Liu
  • , Jie Hu
  • , Paolo Mauri
  • , Raphael Voituriez
  • , Yong Chen
  • , Matthieu Piel

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper reports a novel method to orient both the axis and direction of cell migration, using an array of tilted micropillars. . It is well known that chemical or mechanical clues can bias the direction of cell migration. However, very few investigations have been done on the base of anisotropy of geometrical features in cell locomotion control. Here, we show that surfaces covered by tilted micropillars can direct cell motion in different configurations. The versatility and the robustness of this approach make such kind of structures good candidates for both fundamental research and advanced applications, orienting cells in contact with an artificial surface.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1660-1662
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 1 Jan 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 28 Oct 20121 Nov 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Country/TerritoryJapan
CityOkinawa
Period28/10/121/11/12

Keywords

  • And tilted pillars
  • Cell migration
  • Microstructures
  • Surface engineering

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