DNA and RNA quadruplex ligands

Anne De Cian; Julien Gros; Aurore Guédin; Meriem Haddi; Sébastien Lyonnais; Lionel Guittat; Jean François Riou; Chantal Trentesaux; Barbara Saccà; Laurent Lacroix; Patrizia Alberti; Jean Louis Mergny

doi:10.1093/nass/nrn004

DNA and RNA quadruplex ligands

Anne De Cian
, Julien Gros
, Aurore Guédin
, Meriem Haddi
, Sébastien Lyonnais
, Lionel Guittat
, Jean François Riou
, Chantal Trentesaux
, Barbara Saccà
, Laurent Lacroix
, Patrizia Alberti
, Jean Louis Mergny

CNRS/Museum National d'Histoire Naturelle/IRD/UPMC

Research output: Contribution to journal › Article › peer-review

Abstract

Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes. We explore the binding of a pyridine dicarboxamide derivative to various oligoribo- and oligodeoxyribo-nucleotides.

Original language	English
Pages (from-to)	7-8
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	52
DOIs	https://doi.org/10.1093/nass/nrn004
Publication status	Published - 1 Jan 2008
Externally published	Yes

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10.1093/nass/nrn004

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title = "DNA and RNA quadruplex ligands",

abstract = "Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes. We explore the binding of a pyridine dicarboxamide derivative to various oligoribo- and oligodeoxyribo-nucleotides.",

author = "\{De Cian\}, Anne and Julien Gros and Aurore Gu{\'e}din and Meriem Haddi and S{\'e}bastien Lyonnais and Lionel Guittat and Riou, \{Jean Fran{\c c}ois\} and Chantal Trentesaux and Barbara Sacc{\`a} and Laurent Lacroix and Patrizia Alberti and Mergny, \{Jean Louis\}",

year = "2008",

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doi = "10.1093/nass/nrn004",

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T1 - DNA and RNA quadruplex ligands

AU - De Cian, Anne

AU - Gros, Julien

AU - Guédin, Aurore

AU - Haddi, Meriem

AU - Lyonnais, Sébastien

AU - Guittat, Lionel

AU - Riou, Jean François

AU - Trentesaux, Chantal

AU - Saccà, Barbara

AU - Lacroix, Laurent

AU - Alberti, Patrizia

AU - Mergny, Jean Louis

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes. We explore the binding of a pyridine dicarboxamide derivative to various oligoribo- and oligodeoxyribo-nucleotides.

AB - Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA quadruplexes may be recognized by ligands, it is important to understand the rules that govern the stability and specificity of these complexes. We explore the binding of a pyridine dicarboxamide derivative to various oligoribo- and oligodeoxyribo-nucleotides.

UR - https://www.scopus.com/pages/publications/68549107441

U2 - 10.1093/nass/nrn004

DO - 10.1093/nass/nrn004

M3 - Article

C2 - 18776226

AN - SCOPUS:68549107441

SN - 1746-8272

SP - 7

EP - 8

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 52

ER -

DNA and RNA quadruplex ligands

Abstract

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