DOTASQ as a prototype of nature-inspired G-quadruplex ligand

Loic Stefan; Aurore Guédin; Samir Amrane; Nicole Smith; Franck Denat; Jean Louis Mergny; David Monchaud

doi:10.1039/c0cc04960c

DOTASQ as a prototype of nature-inspired G-quadruplex ligand

Loic Stefan
, Aurore Guédin
, Samir Amrane
, Nicole Smith
, Franck Denat
, Jean Louis Mergny
, David Monchaud

UBFC
Univ. Bordeaux

Research output: Contribution to journal › Article › peer-review

Abstract

DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).

Original language	English
Pages (from-to)	4992-4994
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	17
DOIs	https://doi.org/10.1039/c0cc04960c
Publication status	Published - 7 May 2011
Externally published	Yes

Access to Document

10.1039/c0cc04960c

Cite this

@article{f13dd7f3a8134f05a98d5e1293995c2c,

title = "DOTASQ as a prototype of nature-inspired G-quadruplex ligand",

abstract = "DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).",

author = "Loic Stefan and Aurore Gu{\'e}din and Samir Amrane and Nicole Smith and Franck Denat and Mergny, \{Jean Louis\} and David Monchaud",

year = "2011",

month = may,

day = "7",

doi = "10.1039/c0cc04960c",

language = "English",

volume = "47",

pages = "4992--4994",

journal = "Chemical Communications",

issn = "1359-7345",

number = "17",

}

TY - JOUR

T1 - DOTASQ as a prototype of nature-inspired G-quadruplex ligand

AU - Stefan, Loic

AU - Guédin, Aurore

AU - Amrane, Samir

AU - Smith, Nicole

AU - Denat, Franck

AU - Mergny, Jean Louis

AU - Monchaud, David

PY - 2011/5/7

Y1 - 2011/5/7

N2 - DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).

AB - DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).

U2 - 10.1039/c0cc04960c

DO - 10.1039/c0cc04960c

M3 - Article

C2 - 21431124

AN - SCOPUS:79954445025

SN - 1359-7345

VL - 47

SP - 4992

EP - 4994

JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

DOTASQ as a prototype of nature-inspired G-quadruplex ligand

Abstract

Access to Document

Fingerprint

Cite this