Abstract
We consider a cell population structured by a positive real number x∈R+, which represents the number of P-glycoproteins carried by the cell. These proteins combine two interesting properties: they are involved in the resistance of cancer cells to chemotherapy drugs, and the cells undergo frequent transfers of those proteins. In this article, we introduce a kinetic model to describe the dynamics of the cell population. We then consider an asymptotic limit of this equation: if transfers are frequent, the population can be described through a system of two coupled ordinary differential equations. Finally, we show that the solutions of the kinetic model converge to a unique steady-state in large times. The main idea of this manuscript is to combine Wasserstein distance estimates on the kinetic operator with more classical estimates on the macroscopic quantities.
| Original language | English |
|---|---|
| Article number | 76 |
| Journal | Journal of Mathematical Biology |
| Volume | 91 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Dec 2025 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Asymptotic analysis
- Macroscopic limit
- Mathematical ecology
- Structured population
- Transfer operator
- Wasserstein estimates
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