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Dynamics of a kinetic model describing protein transfers in a cell population

  • IMB UMR 5251

Research output: Contribution to journalArticlepeer-review

Abstract

We consider a cell population structured by a positive real number x∈R+, which represents the number of P-glycoproteins carried by the cell. These proteins combine two interesting properties: they are involved in the resistance of cancer cells to chemotherapy drugs, and the cells undergo frequent transfers of those proteins. In this article, we introduce a kinetic model to describe the dynamics of the cell population. We then consider an asymptotic limit of this equation: if transfers are frequent, the population can be described through a system of two coupled ordinary differential equations. Finally, we show that the solutions of the kinetic model converge to a unique steady-state in large times. The main idea of this manuscript is to combine Wasserstein distance estimates on the kinetic operator with more classical estimates on the macroscopic quantities.

Original languageEnglish
Article number76
JournalJournal of Mathematical Biology
Volume91
Issue number6
DOIs
Publication statusPublished - 1 Dec 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Asymptotic analysis
  • Macroscopic limit
  • Mathematical ecology
  • Structured population
  • Transfer operator
  • Wasserstein estimates

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