Effect of hydrogenated lecithin on cytotoxicity of liposome

Duck Hwan Bae; Jae Sup Shin; Fan Long Jin; Gwi Su Shin; Soo Jin Park

doi:10.5012/bkcs.2009.30.2.339

Effect of hydrogenated lecithin on cytotoxicity of liposome

Duck Hwan Bae
, Jae Sup Shin
, Fan Long Jin
, Gwi Su Shin
, Soo Jin Park

Chungbuk National University
Jilin Institute of Chemical Technology
Jeonbuk Regional Innovation Agency
Inha University

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, a hydrogenated lecithin-containing liposome was prepared using a sonicator and microfluidizer at high shear. The surface tension, particle size, turbidity, and transition temperature (T_c) of the liposome were investigated and compared with the commercially available standard surfactant Tween-60. The cytotoxicities were characterized using the MTT method. The surface tension of hydrogenated lecithin was found to be higher than that of Tween-60. The particle size prepared at above T_cwas smaller than that prepared below T_c. The results of the cytotoxicity experiment indicated that Lecinol 10 exhibits the highest IC₅₀value, which shows its high safety in this study.

Original language	English
Pages (from-to)	339-342
Number of pages	4
Journal	Bulletin of the Korean Chemical Society
Volume	30
Issue number	2
DOIs	https://doi.org/10.5012/bkcs.2009.30.2.339
Publication status	Published - 20 Feb 2009
Externally published	Yes

Keywords

Cytotoxicity
Lecithin
Liposome
Particle size
Turbidity

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10.5012/bkcs.2009.30.2.339

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title = "Effect of hydrogenated lecithin on cytotoxicity of liposome",

abstract = "In this study, a hydrogenated lecithin-containing liposome was prepared using a sonicator and microfluidizer at high shear. The surface tension, particle size, turbidity, and transition temperature (Tc) of the liposome were investigated and compared with the commercially available standard surfactant Tween-60. The cytotoxicities were characterized using the MTT method. The surface tension of hydrogenated lecithin was found to be higher than that of Tween-60. The particle size prepared at above Tcwas smaller than that prepared below Tc. The results of the cytotoxicity experiment indicated that Lecinol 10 exhibits the highest IC50value, which shows its high safety in this study.",

keywords = "Cytotoxicity, Lecithin, Liposome, Particle size, Turbidity",

author = "Bae, \{Duck Hwan\} and Shin, \{Jae Sup\} and Jin, \{Fan Long\} and Shin, \{Gwi Su\} and Park, \{Soo Jin\}",

year = "2009",

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doi = "10.5012/bkcs.2009.30.2.339",

language = "English",

volume = "30",

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journal = "Bulletin of the Korean Chemical Society",

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TY - JOUR

T1 - Effect of hydrogenated lecithin on cytotoxicity of liposome

AU - Bae, Duck Hwan

AU - Shin, Jae Sup

AU - Jin, Fan Long

AU - Shin, Gwi Su

AU - Park, Soo Jin

PY - 2009/2/20

Y1 - 2009/2/20

N2 - In this study, a hydrogenated lecithin-containing liposome was prepared using a sonicator and microfluidizer at high shear. The surface tension, particle size, turbidity, and transition temperature (Tc) of the liposome were investigated and compared with the commercially available standard surfactant Tween-60. The cytotoxicities were characterized using the MTT method. The surface tension of hydrogenated lecithin was found to be higher than that of Tween-60. The particle size prepared at above Tcwas smaller than that prepared below Tc. The results of the cytotoxicity experiment indicated that Lecinol 10 exhibits the highest IC50value, which shows its high safety in this study.

AB - In this study, a hydrogenated lecithin-containing liposome was prepared using a sonicator and microfluidizer at high shear. The surface tension, particle size, turbidity, and transition temperature (Tc) of the liposome were investigated and compared with the commercially available standard surfactant Tween-60. The cytotoxicities were characterized using the MTT method. The surface tension of hydrogenated lecithin was found to be higher than that of Tween-60. The particle size prepared at above Tcwas smaller than that prepared below Tc. The results of the cytotoxicity experiment indicated that Lecinol 10 exhibits the highest IC50value, which shows its high safety in this study.

KW - Cytotoxicity

KW - Lecithin

KW - Liposome

KW - Particle size

KW - Turbidity

UR - https://www.scopus.com/pages/publications/84906254796

U2 - 10.5012/bkcs.2009.30.2.339

DO - 10.5012/bkcs.2009.30.2.339

M3 - Article

AN - SCOPUS:84906254796

SN - 0253-2964

VL - 30

SP - 339

EP - 342

JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

IS - 2

ER -

Effect of hydrogenated lecithin on cytotoxicity of liposome

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Keywords

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