Efficient synthesis of 1,5-disubstituted-1H-tetrazoles by an Ugi-azide process

Luis Edilberto Cárdenas-Galindo; Alejandro Islas-Jácome; Carlos Jesús Cortes-García; Laurent El Kaim; Rocío Gámez-Montaño

Efficient synthesis of 1,5-disubstituted-1H-tetrazoles by an Ugi-azide process

Luis Edilberto Cárdenas-Galindo
, Alejandro Islas-Jácome
, Carlos Jesús Cortes-García
, Laurent El Kaim
, Rocío Gámez-Montaño

Research output: Contribution to journal › Article › peer-review

Abstract

A series of eighteen novel 1,5-disubstituted-1H-tetrazoles has been prepared with moderate to good overall yields using an Ugi-azide reaction as key step under mild conditions. Tetrazoles are heterocyclic systems present in several synthetic products which have privileged biological activity. Therefore, in this paper we describe the synthesis of novel compounds containing the tetrazole moiety, which could present biological activity.

Original language	English
Pages (from-to)	283-289
Number of pages	7
Journal	Journal of the Mexican Chemical Society
Volume	57
Issue number	4
Publication status	Published - 1 Oct 2013
Externally published	Yes

Keywords

1
5 dipolar electro-cyclization
Azide
Isocyanide
Multicomponent reactions
Tetrazole
Ugi-azide

Cite this

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title = "Efficient synthesis of 1,5-disubstituted-1H-tetrazoles by an Ugi-azide process",

abstract = "A series of eighteen novel 1,5-disubstituted-1H-tetrazoles has been prepared with moderate to good overall yields using an Ugi-azide reaction as key step under mild conditions. Tetrazoles are heterocyclic systems present in several synthetic products which have privileged biological activity. Therefore, in this paper we describe the synthesis of novel compounds containing the tetrazole moiety, which could present biological activity.",

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T1 - Efficient synthesis of 1,5-disubstituted-1H-tetrazoles by an Ugi-azide process

AU - Cárdenas-Galindo, Luis Edilberto

AU - Islas-Jácome, Alejandro

AU - Cortes-García, Carlos Jesús

AU - Kaim, Laurent El

AU - Gámez-Montaño, Rocío

PY - 2013/10/1

Y1 - 2013/10/1

N2 - A series of eighteen novel 1,5-disubstituted-1H-tetrazoles has been prepared with moderate to good overall yields using an Ugi-azide reaction as key step under mild conditions. Tetrazoles are heterocyclic systems present in several synthetic products which have privileged biological activity. Therefore, in this paper we describe the synthesis of novel compounds containing the tetrazole moiety, which could present biological activity.

AB - A series of eighteen novel 1,5-disubstituted-1H-tetrazoles has been prepared with moderate to good overall yields using an Ugi-azide reaction as key step under mild conditions. Tetrazoles are heterocyclic systems present in several synthetic products which have privileged biological activity. Therefore, in this paper we describe the synthesis of novel compounds containing the tetrazole moiety, which could present biological activity.

KW - 1

KW - 5 dipolar electro-cyclization

KW - Azide

KW - Isocyanide

KW - Multicomponent reactions

KW - Tetrazole

KW - Ugi-azide

UR - https://www.scopus.com/pages/publications/84892726389

M3 - Article

AN - SCOPUS:84892726389

SN - 1870-249X

VL - 57

SP - 283

EP - 289

JO - Journal of the Mexican Chemical Society

JF - Journal of the Mexican Chemical Society

IS - 4

ER -

Efficient synthesis of 1,5-disubstituted-1H-tetrazoles by an Ugi-azide process

Abstract

Keywords

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